Evaluation of the genotoxic activity and acute toxicity of Euphorbia splendens latex, a molluscicide for the control of schistosomiasis

dc.creatorSchall, Virgínia Torres
dc.creatorVasconcellos, Mauricio Carvalho de
dc.creatorValent, G. U.
dc.creatorSato, Maria Inês Zanoli
dc.creatorFurlan, E. V.
dc.creatorSanchez, P. S.
dc.date2020-01-13T00:36:36Z
dc.date2020-01-13T00:36:36Z
dc.date1991
dc.date.accessioned2023-09-26T23:33:18Z
dc.date.available2023-09-26T23:33:18Z
dc.identifierSCHALL, Virgínia Torres et al. Evaluation of the genotoxic activity and acute toxicity of Euphorbia splendens latex, a molluscicide for the control of schistosomiasis. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 24, p. 573-582, 1991.
dc.identifier0100-879X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39145
dc.identifier1414-431X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891824
dc.descriptionUNDP/WORLD BANK/WHO Special Programme for Research and Training in Tropical Diseases
dc.descriptionCNPq (No. 30.0074/81)
dc.descriptionFAPESP
dc.description1. The latex os Euphorbia splendens var. hislopii has a molluscicidal action at low concentration (LD90 less than 1.5 ppm or 1.5 ug/ml) against the vector snails of schistosomiasis. 2. In the present study, the latex in natura or after lyophilization was submitted to the Ames test and the chromotest to evaluate genotoxicity, to the Microtox System to determine acute toxicity, and to the Chinese hamster ovary cell assay (CHO) to measure cytotoxicity. 3. The latex had no mutagenic activity in the presence or abscence of s9 toward the TA98 and TA100 strains os Salmonella typhimurium (Ames test) at concentrations up to 200 ul/plate (in natura) and of 200 ug/plate (lyophilized). The lyophilized latex had no genotoxic activity (Chromotest) and no acute toxic effect on Photobacterium phosphoreum at concentrations up to 445 ug/ml, whereas the sample in natura had a toxic effect with an EC50 of 148,00 ul/l (or ppm). In the CGO/cytotoxicity assay, the lyophilized latex had no cytotoxic effect in quantities up to 200 ug. 4. The latex was found to have no acute toxicity or mutagenic activity at the concentrations os 10 to 12 ug/ml (or ppm) that are being proposed for molluscicidal use in the field.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.rightsopen access
dc.subjectToxicity assay
dc.subjectMolluscicidal plant
dc.subjectEuphorbia splendens
dc.subjectSchistosomiasis
dc.titleEvaluation of the genotoxic activity and acute toxicity of Euphorbia splendens latex, a molluscicide for the control of schistosomiasis
dc.typeArticle


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