Lipid droplets: platforms with multiple functions in cancer hallmarks

dc.creatorCruz, André L. S.
dc.creatorBarreto, Ester de A.
dc.creatorFazolini, Narayana P. B.
dc.creatorViola, João P. B.
dc.creatorBozza, Patrícia T.
dc.date2020-04-19T18:47:59Z
dc.date2020-04-19T18:47:59Z
dc.date2020
dc.date.accessioned2023-09-26T23:32:43Z
dc.date.available2023-09-26T23:32:43Z
dc.identifierCRUZ, André L. S. et al. Lipid droplets: platforms with multiple functions in cancer hallmarks. Cell Death & Disease, v. 11, n. 105, p. 1-16, 2020.
dc.identifier2041-4889
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40878
dc.identifier10.1038/s41419-020-2297-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891719
dc.descriptionLipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles within leukocytes, epithelial cells, hepatocytes, and other nonadipocyte cells is a frequently observed phenotype in several physiologic or pathogenic situations and is thoroughly described during inflammatory conditions. Moreover, in recent years, several studies have described an increase in intracellular lipid accumulation in different neoplastic processes, although it is not clear whether lipid droplet accumulation is directly involved in the establishment of these different types of malignancies. This review discusses current evidence related to the biogenesis, composition and functions of lipid droplets related to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Nature
dc.rightsopen access
dc.subjectGotículas lipídicas
dc.subjectPlataformas com múltiplas funçõe
dc.subjectMarcadores de Câncer
dc.subjectLipid droplets
dc.subjectCancer hallmarks
dc.subjectPlatforms with multiple functions
dc.titleLipid droplets: platforms with multiple functions in cancer hallmarks
dc.typeArticle


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