Genetic heterogeneity in Trypanosoma cruzi strains from naturally infected triatomine vectors in northeastern Brazil: epidemiological implications

dc.creatorPacheco, Raquel S.
dc.creatorBrito, Célia M. Marques de
dc.creatorSarquis, Otilia
dc.creatorPires, Marize Q.
dc.creatorPereira, José Borges
dc.creatorLima, Marli M.
dc.date2019-12-17T14:57:10Z
dc.date2019-12-17T14:57:10Z
dc.date2005
dc.date.accessioned2023-09-26T23:30:54Z
dc.date.available2023-09-26T23:30:54Z
dc.identifierPACHECO, Raquel S. et al. Genetic Heterogeneity in Trypanosoma cruzi Strains From Naturally Infected Triatomine Vectors in Northeastern Brazil: Epidemiological Implications. Biochemical Genetics, v. 43, n. 9/10, p. 519-530, 2005.
dc.identifier0006-2928
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38654
dc.identifier10.1007/s10528-005-8168-x
dc.identifier1573-4927
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891391
dc.descriptionEighteen Trypanosoma cruzi strains isolated from naturally infected triatomines were studied genetically. The majority of the strains were from Triatoma brasiliensis, the principal vector of Chagas disease in the northeast of Brazil. Multilocus enzyme electrophoresis (MLEE) and randomly amplified polymorphic DNA (RAPD) analyses were used to investigate the genotypic diversity and the spread of the T. cruzi genotypes in different environments. MLEE clearly distinguished two distinct isoenzyme profiles, and RAPD analysis revealed 10 different genotypes circulating in rural areas. The strains could be typed as isoenzyme variants of the T. cruzi principal zymodeme Z1 (T. cruzi I). An effective program of epidemiological vigilance is required to prevent the spread of T. cruzi I strains into human dwellings.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsrestricted access
dc.subjectDoença de Chagas
dc.subjectTrypanosoma cruzi
dc.subjectEpemiologia molecular
dc.subjectTriatomíneos
dc.subjectEletroforese enzimática multifoco
dc.subjectPolimórfico amplificado aleatoriamente
dc.subjectChagas Disease
dc.subjectMLEE
dc.subjectMolecular epidemiology
dc.subjectRAPD
dc.subjectTriatomines
dc.subjectTrypanosoma cruzi
dc.titleGenetic heterogeneity in Trypanosoma cruzi strains from naturally infected triatomine vectors in northeastern Brazil: epidemiological implications
dc.typeArticle


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