Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis

dc.creatorOliveira, Joanna R. Santos
dc.creatorRegis, Eduardo G.
dc.creatorLeal, Cássia R. B.
dc.creatorCunha, Rivaldo V.
dc.creatorBozza, Patrícia T.
dc.creatorCruz, Alda M. da
dc.date2018-04-12T13:23:54Z
dc.date2018-04-12T13:23:54Z
dc.date2011
dc.date.accessioned2023-09-26T23:30:22Z
dc.date.available2023-09-26T23:30:22Z
dc.identifierOLIVEIRA, Joanna R. Santos; et al. Evidence That Lipopolisaccharide May Contribute to the Cytokine Storm and Cellular Activation in Patients with Visceral Leishmaniasis. PLoS Negl Trop Dis., v.5, n.7, e1198, 10p, July 2011.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25799
dc.identifier10.1371/journal.pntd.0001198
dc.identifier1935-2735
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891292
dc.descriptionVisceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negative bacteria that enter the circulation because of immunological mucosal barrier breakdown. As gut parasitization also occurs in VL, it was hypothesized that LPS may be elevated in leishmaniasis, contributing to cell activation.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectLeishmaniose visceral
dc.subjectCitocinas
dc.subjectLipopolissacarídeo
dc.subjectAtivação celular
dc.subjectVisceral Leishmaniasis
dc.subjectLipopolisaccharide
dc.subjectCytokine
dc.subjectCellular Activation
dc.titleEvidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis
dc.typeArticle


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