Chronic phase of Chagas disease: why should it be treated? A comprehensive review

dc.creatorCoura, José Rodrigues
dc.creatorPereira, José Borges
dc.date2017-06-13T16:24:00Z
dc.date2017-06-13T16:24:00Z
dc.date2011
dc.date.accessioned2023-09-26T23:30:01Z
dc.date.available2023-09-26T23:30:01Z
dc.identifierCOURA, José Rodrigues; PEREIRA, José Borges. Chronic phase of Chagas disease: why should it be treated? A comprehensive review. Mem Inst Oswaldo Cruz, v.106, n.6, p.641-645, Sept.2011.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19375
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891230
dc.descriptionThe pathogenesis and evolutive pattern of Chagas disease suggests that the chronic phase should be more widely treated in order to (i) eliminate Trypanosoma cruzi and prevent new inflammatory foci and the extension of tissue lesions, (ii) promote tissue regeneration to prevent fibrosis, (iii) reverse existing fibrosis, (iv) prevent cardiomyopathy, megaoesophagus and megacolon and (v) reduce or eliminate cardiac block and arrhythmia. All cases of the indeterminate chronic form of Chagas disease without contraindications due to other concomitant diseases or pregnancy should be treated and not only cases involving children or recently infected cases. Patients with chronic Chagas cardiomyopathy grade II of the New York Heart Association classification should be treated with specific chemotherapy and grade III can be treated according to medical-patient decisions. We are proposing the following new strategies for chemotherapeutic treatment of the chronic phase of Chagas disease: (i) repeated short-term treatments for 30 consecutive days and interval of 30-60 days for six months to one year and (ii) combinations of drugs with different mechanisms of action, such as benznidazole + nifurtimox, benznidazole or nifurtimox + allopurinol or triazole antifungal agents, inhibition of sterol synthesis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectDoença de Chagas
dc.subjectFase crônica
dc.subjectQuimioterapia
dc.subjectNovas estratégias
dc.subjectCombinação de medicamentos
dc.subjectChagas disease
dc.subjectchronic phase
dc.subjectchemotherapy
dc.subjectnew strategies
dc.subjectrepeated treatment
dc.subjectcombination of drugs
dc.titleChronic phase of Chagas disease: why should it be treated? A comprehensive review
dc.typeArticle


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