Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis

dc.creatorSantos, A. L. S.
dc.creatorSodré, C. L.
dc.creatorValle, R. S.
dc.creatorSilva, B. A.
dc.creatorAbi-chacra, Érika de Araújo
dc.creatorSilva, L. V.
dc.creatorGonçalves, A. L. Souza
dc.creatorSangenito, L. S.
dc.creatorGonçalves, D. S.
dc.creatorSouza, L. O. P.
dc.creatorPalmeira, V. F.
dc.creatord´Avila-Levy, Claudia M.
dc.creatorKneipp, L. F.
dc.creatorKellett, A.
dc.creatorMcCann, M.
dc.creatorBranquinha, M. H.
dc.date2018-06-26T16:47:48Z
dc.date2018-06-26T16:47:48Z
dc.date2012
dc.date.accessioned2023-09-26T23:30:00Z
dc.date.available2023-09-26T23:30:00Z
dc.identifierSANTOS, A. L. S. et al. Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis. Current Medicinal Chemistry, v.19, p.2715-2737, 2012.
dc.identifier0929-8673
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27121
dc.identifier1875-533X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891228
dc.descriptionInfections caused by resistant microorganisms often fail to respond to conventional therapy, resulting in prolonged illness, increased treatment costs and greater risk of death. Consequently, the development of novel antimicrobial drugs is becoming more demanding every day since the existing drugs either have too many side-effects or they tend to lose effectiveness due to the selection of resistant strains. In view of these facts, a number of new strategies to obstruct vital biological processes of a microbial cell have emerged; one of these is focused on the use of metal-chelating agents, which are able to selectively disturb the essential metal metabolism of the microorganism by interfering with metal acquisition and bioavailability for crucial reactions. The chelation activity is able to inhibit the biological role of metal-dependent proteins (e.g., metalloproteases and transcription factors), disturbing the microbial cell homeostasis and culminating in the blockage of microbial nutrition, growth and development, cellular differentiation, adhesion to biotic (e.g., extracellular matrix components, cell and/or tissue) and abiotic (e.g., plastic, silicone and acrylic) structures as well as controlling the in vivo infection progression. Interestingly, chelating agents also potentiate the activity of classical antimicrobial compounds. The differences between the microorganism and host in terms of the behavior displayed in the presence of chelating agents could provide exploitable targets for the development of an effective chemotherapy for these diseases. Consequently, metal chelators represent a novel group of antimicrobial agents with potential therapeutic applications. This review will focus on the anti-fungal and anti-protozoan action of the most common chelating agents, deciphering and discussing their mode of action.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherBentham Science Publishers
dc.rightsrestricted access
dc.subjectQuimioterapia alternativa
dc.subjectatividade antimicrobiana
dc.subjectCrescimento
dc.subjectagentes quelantes
dc.subjectdiferenciação
dc.subjectfungos
dc.subjectInteração
dc.subjectInfecções oportunistas
dc.subjectpatogênese
dc.subjectprotozoários
dc.subjectvirulência
dc.subjectAlternative chemotherapy
dc.subjectantimicrobial activity
dc.subjectchelating agents
dc.subjectgrowth
dc.subjectdifferentiation
dc.subjectfungi
dc.subjectinteraction
dc.subjectopportunistic infections
dc.subjectpathogenesis
dc.subjectprotozoa
dc.subjectvirulence
dc.titleAntimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis
dc.typeArticle


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