Mycobacterium leprae induces NF-jB-dependent transcription repression in human Schwann cells

dc.creatorPereira, Renata M. S.
dc.creatorSilva, Teresa Cristina Calegari
dc.creatorHernandez, Maristela O.
dc.creatorSaliba, Alessandra M.
dc.creatorRedner, Paulo
dc.creatorPessolani, Maria Cristina V.
dc.creatorSarno, Euzenir N.
dc.creatorSampaio, Elizabeth P.
dc.creatorLopez, Ulisses G.
dc.date2019-12-17T14:02:17Z
dc.date2019-12-17T14:02:17Z
dc.date2005
dc.date.accessioned2023-09-26T23:29:16Z
dc.date.available2023-09-26T23:29:16Z
dc.identifierPEREIRA, Renata M. S. et al. Mycobacterium leprae induces NF-jB-dependent transcription repression in human Schwann cells. Biochemical and Biophysical Research Communications, v. 335, p. 20-26, 2005.
dc.identifier0006-291X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38649
dc.identifier10.1016/j.bbrc.2005.07.061
dc.identifier1090-2104
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891101
dc.descriptionMycobacterium leprae, the causative agent of leprosy, invades peripheral nerve Schwann cells, resulting in deformities associated with this disease. NF-jB is an important transcription factor involved in the regulation of host immune antimicrobial responses. We aimed in this work to investigate NF-jB signaling pathways in the human ST88-14 Schwannoma cell line infected with M. leprae. Gel shift and supershift assays indicate that two NF-jB dimers, p65/p50 and p50/p50, translocate to the nucleus in Schwann cells treated with lethally irradiated M. leprae. Consistent with p65/p50 and p50/p50 activation, we observed IjB-a degradation and reduction of p105 levels. The nuclear translocation of p50/p50 complex due to M. leprae treatment correlated with repression of NF-jB-driven transcription induced by TNF-a. Moreover, thalidomide inhibited p50 homodimer nuclear translocation induced by M. leprae and consequently rescues Schwann cells from NF-jB-dependent transcriptional repression. Here, we report for the first time that M. leprae induces NF-jB activation in Schwann cells and thalidomide is able to modulate this activation.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier: 12 months
dc.rightsrestricted access
dc.subjectMycobacterium leprae
dc.subjectHanseníase
dc.subjectCélulas Schwann
dc.subjectTalidomida
dc.subjectRepressão à transcrição
dc.subjectNF-jB
dc.subjectLeprosy
dc.subjectMycobacterium leprae
dc.subjectThalidomide
dc.subjectTranscription repression
dc.subjectSchwann
dc.subjectIjB-a;
dc.subjectp105
dc.subjectp65
dc.subjectp50
dc.titleMycobacterium leprae induces NF-jB-dependent transcription repression in human Schwann cells
dc.typeArticle


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