Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil

dc.creatorPaixão, Enny Santos da
dc.creatorCampbell, Oona M.
dc.creatorTeixeira, Maria Gloria
dc.creatorCosta, Maria da Conceição Nascimento
dc.creatorHarron, Katie
dc.creatorBarreto, Mauricio Lima
dc.creatorLeal, Maira Barreto
dc.creatorAlmeida, Marcia Furquim de
dc.creatorRodrigues, Laura Cunha
dc.date2019-10-01T12:46:23Z
dc.date2019-10-01T12:46:23Z
dc.date2019
dc.date.accessioned2023-09-26T23:29:09Z
dc.date.available2023-09-26T23:29:09Z
dc.identifierPAIXÃO, Enny Santos da et al. Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil. BMJ Open, v. 9, p. 1-8, 2019.
dc.identifier2044-6055
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36026
dc.identifier10.1136/bmjopen-2018-023529
dc.identifier2044-6055
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891078
dc.descriptionNational Council for Scientific and Technological Development (CNPq-Brazil); LR is partially funded by the European Union’s Horizon 2020 research and innovation program under Zika-PLAN grant agreement No. 734584; KH is funded by the Wellcome Trust (grant number 103975/Z/14/Z).
dc.descriptionDengue is the most common viral mosquito-borne disease, and women of reproductive age who live in or travel to endemic areas are at risk. Little is known about the effects of dengue during pregnancy on birth outcomes. The objective of this study is to examine the effect of maternal dengue severity on live birth outcomes. Design and setting We conducted a population-based cohort study using routinely collected Brazilian data from 2006 to 2012. Participating We linked birth registration records and dengue registration records to identify women with and without dengue during pregnancy. Using multinomial logistic regression and Firth method, we estimated risk and ORs for preterm birth (<37 weeks’ gestation), low birth weight (<2500 g) and small for gestational age (<10thcentile). We also investigated the effect of time between the onset of the disease and each outcome. Results We included 16 738 000 live births. Dengue haemorrhagic fever was associated with preterm birth (OR=2.4; 95% CI 1.3 to 4.4) and low birth weight (OR=2.1; 95% CI 1.1 to 4.0), but there was no evidence of effect for small for gestational age (OR=2.1; 95% CI 0.4 to 12.2). The magnitude of the effects was higher in the acute disease period. Conclusion This study showed an increased risk of adverse birth outcomes in women with severe dengue during pregnancy. Medical intervention to mitigate maternal risk during severe acute dengue episodes may improve outcomes for infants born to exposed mothers.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMJ Publishing Group
dc.rightsopen access
dc.subjectDengue
dc.subjectGravidez
dc.subjectNascidos vivos
dc.subjectEstudos de Coortes
dc.subjectNascimento
dc.subjectBrasil
dc.subjectDengue
dc.subjectPregnancy
dc.subjectLive Birth
dc.subjectCohort Studies
dc.subjectParturition
dc.subjectBrazil
dc.titleDengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil
dc.typeArticle


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