The central role of Fas-ligand cell signaling in inflammatory lung diseases.

dc.creatorDosReis, George Alexandre
dc.creatorBorges, Valeria de Matos
dc.creatorZin, Walter Araujo
dc.date2015-02-10T14:22:32Z
dc.date2015-02-10T14:22:32Z
dc.date2004
dc.date.accessioned2023-09-26T23:29:00Z
dc.date.available2023-09-26T23:29:00Z
dc.identifierDosREIS, G. A.; BORGES, V. M.; ZIN, W. A. The central role of Fas-ligand cell signaling in inflammatory lung diseases. Journal of Cellular and Molecular Medicina, v. 8, n. 3, p. 285-293, 2004.
dc.identifier1582-1838
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9472
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891051
dc.descriptionFollowing inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas-Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL-1 beta and chemokine release, leading to neutrophil infiltration. FasL signaling plays a critical role in models of acute lung injury, idiopathic pulmonary fibrosis and silicosis; blockade of Fas-FasL interactions either prevents or attenuates pulmonary inflammation and fibrosis. Serologic and immunohistochemical studies in patients support a major pathogenic role of Fas and FasL molecules in inflammatory lung diseases. Identification of the pathogenic role of FasL could facilitate the discovery of more effective treatments for currently untreatable inflammatory lung diseases
dc.formatapplication/pdf
dc.languageeng
dc.publisheropen access
dc.rightsopen access
dc.subjectFas ligand
dc.subjectApoptosis
dc.subjectInflammation
dc.subjectNeutrophil
dc.subjectMacrophage
dc.subjectPhagocytosis
dc.subjectFibrosis
dc.subjectLung
dc.subjectInjury
dc.subjectSilicosis
dc.subjectAntígenos CD95/imunologia
dc.subjectGlicoproteínas de Membrana/fisiologia
dc.subjectPneumonia/imunologia
dc.subjectDoença Aguda
dc.subjectApoptose
dc.subjectCélulas Epiteliais/metabolismo
dc.subjectProteína Ligante Fas
dc.subjectRegulação da Expressão Gênica
dc.subjectHumanos
dc.subjectInterleucina-1/metabolismo
dc.subjectMacrófagos Alveolares/imunologia
dc.subjectNeutrófilos/imunologia
dc.subjectPneumonia/metabolismo
dc.subjectAlvéolos Pulmonares/imunologia
dc.subjectFibrose Pulmonar/imunologia
dc.subjectTransdução de Sinal
dc.subjectSilicose/imunologia
dc.titleThe central role of Fas-ligand cell signaling in inflammatory lung diseases.
dc.typeArticle


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