Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice

dc.creatorTorres, Dilênia de Oliveira Cipriano
dc.creatorSantos, Ana Célia Oliveira Dos
dc.creatorSilva, Amanda Karolina Soares e
dc.creatorMoura, Patrícia Muniz Mendes Freire de
dc.creatorBeltrão, Eduardo Isidoro Carneiro
dc.creatorPeixoto, Christina Alves
dc.date2018-09-06T12:14:41Z
dc.date2018-09-06T12:14:41Z
dc.date2012
dc.date.accessioned2023-09-26T23:28:37Z
dc.date.available2023-09-26T23:28:37Z
dc.identifierTORRES, Dilênia de Oliveira Cipriano et al. Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice. International Journal of Clinical and Experimental Medicine, v. 5, n. 1, p. 56–63, 2012.
dc.identifier1940-5901
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28577
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890982
dc.descriptionFundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Fundação de Apoio ao Desenvolvimento Científico de Pernambuco (FACEPE).
dc.descriptionAIMS: The present study investigated the effect of a maternal diet rich in omega-6 (E6D) or omega-9 (E9D) on atherogenesis in the offspring of mice. MAIN METHODS: LDL receptor-deficient mice were fed a diet rich in either omega-6 (E6D) or omega-9 (E9D) for 45 days prior to mating and until the birth of the offspring, evaluating the effect on the offspring aorta in comparison to a standard diet (STD), by immunohistochemical analysis, morphometric analysis and electron microscopy. KEY FINDINGS: Hypercholesterolemic female mice fed E6D generated offspring with high levels of total cholesterol, triglycerides (TG) and CC-chemokine ligand 2/monocyte chemoattractant protein 1 (CCL2/ MCP-1) as well as a reduction in high-density lipoprotein. The ascending aorta of these animals exhibited an increase in arterial wall thickness as well as increased expression of CCL2/MCP-1 and vascular cell adhesion molecule 1. The ultrastructural analysis revealed severe alterations in endothelial cells. The offspring from mothers fed E9D exhibited a reduction in TG and an increase in low-density lipoprotein. The ultrastructural analysis revealed a well-preserved aortic endothelium in these animals. SIGNIFICANCE: The results suggest that hypercholesterolemic mothers feed a diet rich in omega-6 predispose their offspring to endothelial dysfunction.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectNutrição materna
dc.subjectHipercolesterolemia materna
dc.subjectÔmega-6
dc.subjectÔmega-9
dc.subjectProle
dc.subjectMCP-1
dc.subjectVCAM-1
dc.subjectAterogênese
dc.subjectLipídios sangüíneos
dc.subjectMaternal nutrition
dc.subjectMaternal hypercholesterolemia
dc.subjectOmega-6
dc.subjectOmega-9
dc.subjectOffspring
dc.subjectMCP-1
dc.subjectVCAM-1
dc.subjectAtherogenesis
dc.subjectBlood lipids
dc.titleInfluence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice
dc.typeArticle


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