| dc.creator | Bessa, Theolis Costa Barbosa | |
| dc.creator | Barral Netto, Manoel | |
| dc.date | 2013-11-25T19:29:46Z | |
| dc.date | 2013-11-25T19:29:46Z | |
| dc.date | 2013 | |
| dc.date.accessioned | 2023-09-26T23:28:17Z | |
| dc.date.available | 2023-09-26T23:28:17Z | |
| dc.identifier | BARBOSA, T.; BARBOSA, T. Challenges in the research and development of new human vaccines. Brazilian Journal of Medical and Biological Research, v. 46, n. 2, p.103-108, 2013. | |
| dc.identifier | 1414-431X | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/7261 | |
| dc.identifier | 10.1590/1414-431X20131873 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8890921 | |
| dc.description | The field of vaccinology was born from the observations by the fathers of vaccination, Edward Jenner and Louis Pasteur, that a
permanent, positive change in the way our bodies respond to life-threatening infectious diseases can be obtained by specific
challenge with the inactivated infectious agent performed in a controlled manner, avoiding the development of clinical disease
upon exposure to the virulent pathogen. Many of the vaccines still in use today were developed on an empirical basis,
essentially following the paradigm established by Pasteur, ‘‘isolate, inactivate, and inject’’ the disease-causing microorganism,
and are capable of eliciting uniform, long-term immune memory responses that constitute the key to their proven efficacy.
However, vaccines for pathogens considered as priority targets of public health concern are still lacking. The literature tends to
focus more often on vaccine research problems associated with specific pathogens, but it is increasingly clear that there are
common bottlenecks in vaccine research, which need to be solved in order to advance the development of the field as a whole.
As part of a group of articles, the objective of the present report is to pinpoint these bottlenecks, exploring the literature for
common problems and solutions in vaccine research applied to different situations. Our goal is to stimulate brainstorming
among specialists of different fields related to vaccine research and development. Here, we briefly summarize the topics we
intend to deal with in this discussion. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Faculdade de Medicina de Ribeirao Preto | |
| dc.rights | open access | |
| dc.subject | Human vaccines | |
| dc.subject | Vaccine issues | |
| dc.subject | Vaccine efficacy | |
| dc.subject | Immunization strategies | |
| dc.title | Challenges in the research and development of new human vaccines | |
| dc.type | Article | |
