The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi

dc.creatorSales Junior, Policarpo A.
dc.creatorGolgher, Denise
dc.creatorOliveira, Roberta V.
dc.creatorVieira, Valeska
dc.creatorArantes, Rosa M. E.
dc.creatorLannes-Vieira, Joseli
dc.creatorGazzinelli, Ricardo T.
dc.date2018-08-16T13:50:48Z
dc.date2018-08-16T13:50:48Z
dc.date2008
dc.date.accessioned2023-09-26T23:28:02Z
dc.date.available2023-09-26T23:28:02Z
dc.identifierSALES JUNIOR, Policarpo A. et al. The regulatory CD4þCD25þ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi. Microbes and Infection, v.10, p.680-688, 2008.
dc.identifier1286-4579
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28180
dc.identifier10.1016/j.micinf.2008.03.008
dc.identifier1769-714X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890874
dc.descriptionRecent reports have established an important role of CD4+CD25+ T cells in the immune regulation of infectious diseases, autoimmune disorders and cancer. In the present work, we investigated whether these cells had a regulatory role during Trypanosoma cruzi infection, using the Colombian strain. Inactivation of CD4+CD25+ cells in vivo conferred mice slightly more resistant to infection with the Colombian strain of T. cruzi, as evidenced by lower parasitemia and mortality rates. The augmented resistance to infection with Colombian strain did correlate with increased activation of effector CD4 cells. It was antibody-independent, since no difference in levels of IgM, IgG, IgG1 and IgG2a(b) recognizing T. cruzi antigens was observed throughout the infection of CD25-inactivated and control mice. Regarding pathogenesis, inflammatory infiltrate and frequency of CD4 and CD8 T cells or macrophages in the cardiac tissue was similar in both groups. Together, our data indicate that CD4+CD25+ cells have a limited role on host resistance during early T. cruzi infection. Despite exhaustive investigation, we did not observe any role for these regulatory cells in the pathogenesis of experimental chronic Chagas' disease.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectCD4+CD25+
dc.subjectLinfócitos T Reguladores
dc.subjectTrypanosoma cruzi
dc.subjectRegulatory T cells
dc.subjectCD4+CD25+
dc.titleThe regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi
dc.typeArticle


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