Brasil | Article

Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals

dc.creatorSouza, Marina de Assis
dc.creatorCastro, Maria C. A. Brelaz de
dc.creatorOliveira, Andresa Pereira de
dc.creatorAlmeida, Amanda Ferreira de
dc.creatorAlmeida, Thays Miranda de
dc.creatorReis, Luiza C.
dc.creatorMedeiros, Ângela Cristina Rapela
dc.creatorBrito, Maria Edileuza Felinto de
dc.creatorPereira, Valéria Rêgo Alves
dc.date2017-12-15T12:19:28Z
dc.date2017-12-15T12:19:28Z
dc.date2013
dc.date.accessioned2023-09-26T23:27:56Z
dc.date.available2023-09-26T23:27:56Z
dc.identifierSOUZA, M. de Assis et al. Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals. Microbial Pathogenesis, v. 57, p. 27–32, abr. 2013.
dc.identifier1096-1208
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23666
dc.identifier10.1016/j.micpath.2013.02.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890854
dc.descriptionStudies suggest the influence of immune response on the successful treatment of American tegumentary leishmaniasis (ATL), and indicate the existence of protective immunity in self-healed patients. Thus, the aim of this work was to quantify interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin (IL-) 10, IL-17, IL-22 and nitric oxide (NO) in culture supernatants of PBMC from patients with active disease (AD), after treatment (AT), and from self-healed (SH) and healthy subjects (CT), in response to Leishmania (Viannia) braziliensis insoluble antigen (AgIns). All groups of patients produced IFN-γ, indicating a predominant proinflammatory profile. AD and AT patients presented TNF-α levels, with a slight increase after therapy, whereas it was weakly quantified in SH. Interestingly, NO secretion was significant in these individuals, whereas IL-17 appeared in low levels and seems to be regulated by NO. Although IL-22 was detected in AD, its role is still questionable. The presence of IL-10 in all groups of patients suggests that the cytokine plays distinct roles in the disease. These results indicate that specific cellular immunity takes part against Leishmania, but with some similarities between the different clinical states herein described; these mediators seem to be necessary for the cure to occur.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCitocinas
dc.subjectImunidade celular
dc.subjectLeishmania braziliensis
dc.subjectLeishmaniose
dc.subjectÓxido nítrico
dc.subjectCytokines
dc.subjectCellular immunity
dc.subjectLeishmania braziliensis
dc.subjectLeishmaniasis
dc.subjectNitric oxide
dc.subjectCitocinas
dc.subjectbiossíntese
dc.subjectLeishmania braziliensis
dc.subjectimunologia
dc.subjectLeishmaniose Cutânea
dc.subjectimunologia
dc.subjectLeishmaniose Cutânea
dc.subjectmetabolismo
dc.subjectÓxido Nítrico
dc.subjectbiossíntese
dc.subjectAdulto
dc.subjectIdoso
dc.subjectHumanos
dc.subjectIdoso de 80 Anos ou mais
dc.subjectAntígenos de Protozoários
dc.subjectimunologia
dc.subjectCitocinas
dc.subjectimunologia
dc.subjectFeminino
dc.subjectMasculino
dc.subjectLeucócitos Mononucleares
dc.subjectimunologia
dc.subjectLeucócitos Mononucleares
dc.subjectmetabolismo
dc.subjectMeia-Idade
dc.subjectAdulto Jovem
dc.titleCytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals
dc.typeArticle


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