Immunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae

dc.creatorGonçalves, Pamela Rosa
dc.creatorSousa, Luciana Pereira de
dc.creatorGomes, Flávia Lima Ribeiro
dc.creatorCarvalho, Leonardo José Moura
dc.creatorRibeiro, Cláudio Tadeu Daniel
dc.date2023-03-24T12:15:57Z
dc.date2023-03-24T12:15:57Z
dc.date2023
dc.date.accessioned2023-09-26T23:27:45Z
dc.date.available2023-09-26T23:27:45Z
dc.identifierGONÇALVES, Pamela Rosa et al. Immunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae. Brain, Behavior, and Immunity, v. 109, p. 102-104, 2023.
dc.identifier0889-1591
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/57546
dc.identifier10.1016/j.bbi.2023.01.007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890821
dc.descriptionMalaria, an ancient infectious parasitic disease, is caused by protozoa of the genus Plasmodium, whose erythrocytic cycle is accompanied by fever, headache, sweating and chills and a systemic inflammation that can progress to severe forms of disease, including cerebral malaria. Approximately 25% of survivors of this syndrome develop sequelae that may include neurological, neurocognitive, behavioral alterations and poor school performance. Furthermore, some outcomes have also been recorded following episodes of non-severe malaria, which correspond to the most common clinical form of the disease worldwide. There is a body of evidence that neuroinflammation, due to systemic inflammation, plays an important role in the neuropathogenesis of malaria culminating in these cognitive dysfunctions. Preclinical studies suggest that vaccination with type 2 immune response elicitors, such as the tetanus-diphtheria (Td) vaccine, may exert a beneficial immunomodulatory effect by alleviating neuroinflammation. In this viewpoint article, vaccination is proposed as a therapy approach to revert or mitigate neurocognitive deficits associated with malaria.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectMalária
dc.subjectDisfunção cognitiva
dc.subjectImunomodulação
dc.subjectVacina contra tétano-difteria
dc.subjectMelhorador cognitivo
dc.subjectMalaria
dc.subjectCognitive dysfunction
dc.subjectImmunomodulation
dc.subjectTetanus-diphtheria vaccine
dc.subjectCognitive enhancer
dc.titleImmunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae
dc.typeArticle


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