Fractional Laser Resurfacing Treats Photoaging by Promoting Neocollegenesis and Cutaneous Edema

dc.creatorBorges, Juliano
dc.creatorAraújo, Luciana
dc.creatorCuzzi, Tullia
dc.creatorMartinez, Luis
dc.creatorGonzales, Yliana
dc.creatorManela-Azulay, Mônica
dc.date2020-10-13T14:04:20Z
dc.date2020-10-13T14:04:20Z
dc.date2020
dc.date.accessioned2023-09-26T23:27:35Z
dc.date.available2023-09-26T23:27:35Z
dc.identifierBORGES, Juliano et al. Fractional Laser Resurfacing Treats Photoaging by Promoting Neocollegenesis and Cutaneous Edema. The Journal of Clinical and Aesthetic Dermatology, v. 13, n. 1, p. 22-27, 2020.
dc.identifier1941-2789
dc.identifierPMID: 32082467
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/43962
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890792
dc.descriptionBACKGROUND: Laser resurfacing is a common treatment for photoaging. This treatment creates skin incisions that initiate the wound healing cascade, including reorganization of the collagen matrix, in a dermal remodeling process that can last up to 12 months. OBJECTIVE: We compared the effects of nonablative and ablative Erbium fractional laser resurfacing on dermal content and arrangement of Collagen Types I and III, and on fibroblast activation. METHODS: Ten female patients (50-63 years) with Fitzpatrick Skin Types I-IV and clinical signs of photoaging underwent two types of Erbium fractional laser resurfacing (nonablative, 1540nm; ablative, 2940nm) on opposite sides of the face. Skin biopsies were obtained pretreatment and three months post-treatment. Morphometric analysis was performed using Picrosirius staining for overall collagen, and immunohistochemistry for Collagen Types I and III. Finally, hematoxylin and eosin staining was used to identify fibroblast activation. RESULTS: Both laser treatments induced reorganization of Collagen Types I and III and demonstrated signs of fibroblast activation. However, morphometric analysis of Picrosirius staining revealed that, after both treatments, there was a lower density of collagen fibers, which is characteristic of edema. CONCLUSION: At three months after laser resurfacing, skin lifting in photoaged skin likely resulted from new collagen deposition but also from edema.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMatrix Medical Communications
dc.rightsopen access
dc.subjectCollagen Type I
dc.subjectCollagen Type III
dc.subjectErbium fractional laser resurfacing
dc.subjectAblative
dc.subjectAging skin
dc.subjectNonablative
dc.subjectPhotoaging
dc.subjectRejuvenation
dc.subjectSolar elastosis
dc.titleFractional Laser Resurfacing Treats Photoaging by Promoting Neocollegenesis and Cutaneous Edema
dc.typeArticle


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