Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response

dc.creatorAlbuquerque, Juliana Barreto de
dc.creatorSantos, Danielle Silva dos
dc.creatorStein, Jens V.
dc.creatorMeis, Juliana de
dc.date2019-01-29T16:35:19Z
dc.date2019-01-29T16:35:19Z
dc.date2018
dc.date.accessioned2023-09-26T23:26:16Z
dc.date.available2023-09-26T23:26:16Z
dc.identifierALBUQUERQUE, Juliana Barreto de; et al. Oral versus intragastric inoculation: Similar Pathways of Trypanosoma cruzi experimental infection? From Target Tissues, Parasite evasion, and immune Response. Frontiers in Immunology, v.9, Article 1734, 9p, July 2018.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31349
dc.identifier10.3389/fimmu.2018.01734
dc.identifier1664-3224
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890554
dc.descriptionCurrently, oral infection is the most frequent transmission mechanism of Chagas disease in Brazil and others Latin American countries. This transmission pathway presents increased mortality rate in the first 2 weeks, which is higher than the calculated mortality after the biting of infected insect vectors. Thus, the oral route of Trypanosoma cruzi infection, and the consequences in the host must be taken into account when thinking on the mechanisms underlying the natural history of the disease. Distinct routes of parasite entry may differentially affect immune circuits, stimulating regional immune responses that impact on the overall profile of the host protective immunity. Experimental studies related to oral infection usually comprise inoculation in the mouth (oral infection, OI) or gavage (gastrointestinal infection, GI), being often considered as similar routes of infection. Hence, establishing a relationship between the inoculation site (OI or GI) with disease progression and the mounting of T. cruzi-specific regional immune responses is an important issue to be considered. Here, we provide a discussion on studies performed in OI and GI in experimental models of acute infections, including T. cruzi infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectCavidade oral
dc.subjectIinfecção intragástrica
dc.subjectResposta imune
dc.subjectAtivação das Células T
dc.subjectTrypanosoma cruzi
dc.subjectoral cavity
dc.subjectintragastric infection
dc.subjectimmune response
dc.subjectT cell activation
dc.titleOral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
dc.typeArticle


Este ítem pertenece a la siguiente institución