HIV-1 subtyping in Salvador, Bahia, Brazil: a city with African sociodemographic characteristics

dc.creatorFernandez, José Carlos Couto
dc.creatorMorgado, Mariza Gonçalves
dc.creatorBongertz, Vera
dc.creatorTanuri, Amilcar
dc.creatorAndrade, Tarcisio Mattos de
dc.creatorAlves, Carlos Roberto Brites
dc.creatorCastro Filho, Bernardo Galvão
dc.date2012-10-04T20:34:19Z
dc.date2012-10-04T20:34:19Z
dc.date1999
dc.date.accessioned2023-09-26T23:26:01Z
dc.date.available2023-09-26T23:26:01Z
dc.identifierCOUTO-FERNANDEZ, J.C. et al. HIV-1 subtyping in Salvador, Bahia, Brazil: a city with African sociodemographic characteristics. Journal of Acquired Immune Deficience Syndromes v. 22, n. 3, p. 288-93, nov. 1999.
dc.identifier1525-4135
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5646
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890519
dc.descriptionTo investigate the prevalence of the HIV-1 subtypes in different populations from Salvador, Bahia, Brazil, blood samples from 72 HIV-1-seropositive injecting drug users (IDUs) and 62 individuals infected sexually were analyzed using the heteroduplex mobility assay (HMA). In the IDU group, 89.5% were classified as subtype B, 3% as subtype F, and 7.5% showed a B/F HMA profile. In the sexual transmission (ST) group, 95% were identified as B subtype, 3.4% showed a B/F profile, and 1.6% a B/C/E HMA profile. All Brazilian samples that showed multiple reactivities in the HMA analysis clustered on sequencing with B North American/ European HIV-1 isolates in the phylogenetic analysis, whereas the F subtypes clustered with F Brazilian HIV-I isolates. Serologic reactivities of IDU's sera were examined using a panel of synthetic V3 loop peptides representative of the different HIV-1 subtypes. No difference in serologic reactivity between F and B subtype plasma could be observed. Predominance of HIV-I subtype B was identified in both study groups, whereas subtype F was detected only among IDUs in a frequency lower than described for other Brazilian regions.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHIV-1
dc.subjectSubtypes
dc.subjectDiversity
dc.subjectBrazil
dc.subjectVariação Antigênica
dc.subjectInfecções por HIV/virologia
dc.subjectHIV-1/classificação
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectÁfrica/etnologia
dc.subjectGrupo com Ancestrais do Continente Africano
dc.subjectBrasail
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectFeminino
dc.subjectInfecções por HIV/imunologia
dc.subjectInfecções por HIV/transmissão
dc.subjectHIV-1/imunologia
dc.subjectAnálise Heteroduplex
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectFilogenia
dc.subjectReação em Cadeia da Polimerase
dc.subjectComportamento Sexual
dc.subjectFatores Socioeconômicos
dc.subjectAbuso de Substâncias por Via Intravenosa/complicações
dc.titleHIV-1 subtyping in Salvador, Bahia, Brazil: a city with African sociodemographic characteristics
dc.typeArticle


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