The effects of low laser irradiation on angiogenesis in injured rat tibiae

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGaravello, I.
dc.creatorBaranauskas, V.
dc.creatorDa Cruz-Höfling, Maria Alice
dc.date2014-05-27T11:21:01Z
dc.date2016-10-25T18:19:19Z
dc.date2014-05-27T11:21:01Z
dc.date2016-10-25T18:19:19Z
dc.date2004-01-01
dc.date.accessioned2017-04-06T01:08:15Z
dc.date.available2017-04-06T01:08:15Z
dc.identifierHistology and Histopathology, v. 19, n. 1, p. 43-48, 2004.
dc.identifier0213-3911
dc.identifierhttp://hdl.handle.net/11449/67615
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67615
dc.identifier2-s2.0-1642474414.pdf
dc.identifier2-s2.0-1642474414
dc.identifierhttp://hdl.handle.net/11449/67615
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889044
dc.descriptionThe influence of He-Ne laser radiation on the formation of new blood vessels in the bone marrow compartment of a regenerating area of the mid-cortical diaphysis of the tibiae of young adult rats was studied. A small hole was surgically made with a dentistry burr in the tibia and the injured area received a daily laser therapy over 7 or 14 days transcutaneously starting 24 h from surgery. Incident energy density dosages of 31.5 and 94.5 Jcm-2 were applied during the period of the tibia wound healing investigated. Light microscopic examination of histological sections of the injured area and quantification of the newly-formed blood vessels were undertaken. Low-level energy treatment accelerated the deposition of bone matrix and histological characteristics compatible with an active recovery of the injured tissue. He-Ne laser therapy significantly increased the number of blood vessels after 7 days irradiation at an energy density of 94.5 Jcm-2, but significantly decreased the number of vessels in the 14-day irradiated tibiae, independent of the dosage. These effects were attributed to laser treatment, since no significant increase in blood vessel number was detected between 8 and 15 non-irradiated control tibiae. Molecular mechanisms involved in low-level laser therapy of angiogenesis in post-traumatic bone regeneration needs further investigation.
dc.languageeng
dc.relationHistology and Histopathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAngiogenesis
dc.subjectBone wound healing
dc.subjectHe-Ne laser
dc.subjectRat
dc.subjectTibia
dc.subjectangiogenesis
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbone injury
dc.subjectbone marrow
dc.subjectbone matrix
dc.subjectbone regeneration
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcortical bone
dc.subjectdensity
dc.subjectdiaphysis
dc.subjecthelium neon laser
dc.subjecthistology
dc.subjectlow level laser therapy
dc.subjectmale
dc.subjectmicroscopy
dc.subjectmolecular dynamics
dc.subjectnonhuman
dc.subjectquantitative analysis
dc.subjectradiation dose
dc.subjectrat
dc.subjecttibia
dc.subjectwound healing
dc.subjectAnimals
dc.subjectHelium
dc.subjectLaser Therapy, Low-Level
dc.subjectLasers
dc.subjectMale
dc.subjectNeon
dc.subjectNeovascularization, Physiologic
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.subjectWound Healing
dc.subjectAnimalia
dc.titleThe effects of low laser irradiation on angiogenesis in injured rat tibiae
dc.typeOtro


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