Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate

dc.creatorKratz, Jadel Müller
dc.creatorAndrighetti-Fröhner, Carla Regina
dc.creatorKolling, Deise Juliana
dc.creatorLeal, Paulo César
dc.creatorSantos, Cláudio César Cirne
dc.creatorYunes, Rosendo Augusto
dc.creatorNunes, Ricardo José
dc.creatorTrybala, Edward
dc.creatorBergström, Tomas
dc.creatorFrugulhetti, Izabel C. P. P.
dc.creatorBarardi, Célia Regina Monte
dc.creatorSimões, Cláudia Maria Oliveira
dc.date2018-09-22T20:58:54Z
dc.date2018-09-22T20:58:54Z
dc.date2008
dc.date.accessioned2023-09-26T23:25:35Z
dc.date.available2023-09-26T23:25:35Z
dc.identifierKRATZ, Jadel Müller; et al. Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate. Mem Inst Oswaldo Cruz , v.103, n.5, p. 437-442, Aug. 2008.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28992
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890443
dc.descriptionThe synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectAntivirais
dc.subjectHIV-1
dc.subjectHerpesvirus Humano 1
dc.subjectÁcido Gálico
dc.subjectantiviral
dc.subjectHSV-1
dc.subjectHIV-1
dc.subjectgallic acid
dc.subjectpentyl gallate
dc.titleAnti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
dc.typeArticle


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