Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil

dc.creatorBarbosa, Cynara Gomes
dc.creatorSouza, Claudio Lima
dc.creatorMoura Neto, José Pereira de
dc.creatorArruda, Maria da Gloria Bomfim
dc.creatorBarreto, José Henrique Silva
dc.creatorReis, Mitermayer Galvão dos
dc.creatorGonçalves, Marilda de Souza
dc.date2013-01-14T18:12:51Z
dc.date2013-01-14T18:12:51Z
dc.date2008
dc.date.accessioned2023-09-26T23:24:53Z
dc.date.available2023-09-26T23:24:53Z
dc.identifierBARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008.
dc.identifier1415-4757
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6181
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890320
dc.descriptionMethylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigateMTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAML
dc.subjectCML
dc.subjectMTHFR polymorphisms
dc.subjectMetilenotetraidrofolato Redutase (NADPH2)
dc.subjectLeucemia Mielóide
dc.subjectFrequência do Gene
dc.subjectLeucemia Mielogênica Crônica BCR-ABL Positiva
dc.subjectPolimorfismo de Fragmento de Restrição
dc.subjectReação em Cadeia da Polimerase
dc.subjectMutação
dc.subjectHumanos
dc.subjectMasculino
dc.subjectFeminino
dc.subjectCriança
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectMeia-Idade
dc.subjectIdoso
dc.titleMethylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
dc.typeArticle


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