Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection

dc.creatorAmaral, Eduardo Pinheiro
dc.creatorAndrade, Bruno de Bezerril
dc.date2017-09-25T17:59:16Z
dc.date2017-09-25T17:59:16Z
dc.date2017
dc.date.accessioned2023-09-26T23:23:42Z
dc.date.available2023-09-26T23:23:42Z
dc.identifierAMARAL, E. P.; ANDRADE, B. B. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection. Clinical Medicine Insights: Case Reports, v. 9, p. 1-10, 2017.
dc.identifier1178-6450
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/21099
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890102
dc.descriptionThe interactions between pathogens and host cells and the way by which the immune response is modulated during this process ultimately dictate the fate of infection. Host phagocytes exposed to Mycobacterium tuberculosis (M. tuberculosis) sense microbial-associated molecular patterns and activate a series of signaling pathways. In this setting, activation of the nuclear factor κB (NF-κB) initiates transcription of several key genes involved in orchestration of antimycobacterial effector functions. This review describes these major pathways that govern the outcome of host phagocytes infected with M. tuberculosis. Furthermore, we highlight evidence of how M. tuberculosis modulates activation of NF-κB pathways to evade the host antimycobacterial defense.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLibertas Academica
dc.rightsopen access
dc.subjectMycobactérias
dc.subjectSensores
dc.subjectNF-κappa B
dc.subjectHospedeiro
dc.subjectMycobacterium tuberculosis
dc.subjectMycobacteria
dc.subjectImmune sensors
dc.subjectNF-κB pathways
dc.subjectHost defense
dc.subjectMycobacterium tuberculosis
dc.titleNuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
dc.typeArticle


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