Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective

dc.creatorSilva, Gabriela Porto Santos Almeida
dc.creatorOliveira, Rodrigo Cunha
dc.creatorSouza, Juliana Sacramento Mota de
dc.creatorGiovanetti, Marta
dc.creatorGuimarães, Monick Lindenmeyer
dc.creatorBrites, Carlos
dc.creatorCunha, Joana Paixão Monteiro
dc.date2023-01-26T17:29:09Z
dc.date2023-01-26T17:29:09Z
dc.date2022
dc.date.accessioned2023-09-26T23:22:38Z
dc.date.available2023-09-26T23:22:38Z
dc.identifierSILVA, Gabriela Porto Santos Almeida et al. Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220109, p. 1 - 7, 2022.
dc.identifier0074-0206
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56641
dc.identifier10.1590/0074-02760220109
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889902
dc.descriptionEurope, and South America. In Brazil, this sub-subtype co-circulates with subtypes B and C and several recombinant forms, mainly BF1 variants. OBJECTIVES This study aimed to reconstruct the dynamic history of HIV-1 F1 in Brazil. METHODS HIV-1 near full-length genome and pol gene nucleotide sequences available in public databases were assembled in two datasets (POL671 and NFLG53) to cover the largest number of F1 sub-subtype sequences. Phylodynamic and temporal analyses were performed. FINDINGS Two main strains of the F1 sub-subtype are circulating worldwide. The first (F1.I) was found among Brazilian samples (75%) and the second (F1.II) among Romanian (62%) and other European and African isolates. The F1 subtype epidemic in Brazil originated from a single entry into the country around 1970. This ancestral sample is related to samples isolated in European countries (France, Finland, and Belgium), which are possibly of African origin. Moreover, further migration (1998 CI: 1994-2003) of strains from Brazil to Europe (Spain and the UK) was observed. Interestingly, all different recombinant BF patterns found, even those from outside Brazil, present the same F1 lineage (F1.I) as an ancestor, which could be related to the acquisition of adaptive advantages for the recombinant progenies. MAIN CONCLUSIONS These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectHIV
dc.subjectF1 sub-subtipo
dc.subjectFilodinâmica
dc.subjectRecombinantes
dc.subjectBF1
dc.subjectHIV
dc.subjectF1 sub-subtype
dc.subjectPhylodynamic
dc.subjectRecombinants
dc.subjectBF1
dc.titleTracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective
dc.typeArticle


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