Monocytes from HTLV-1 infected patients are unable to fully maturate into dendritic cells

dc.creatorNascimento, Clarissa Rodrigues
dc.creatorLima, Marco Antonio
dc.creatorSerpa, Maria José de Andrada
dc.creatorEspindola, Otávio
dc.creatorLeite, Ana Claudia Celestino
dc.creatorEchevarria-Lima, Juliana
dc.date2019-11-06T15:00:07Z
dc.date2019-11-06T15:00:07Z
dc.date2011
dc.date.accessioned2023-09-26T23:22:14Z
dc.date.available2023-09-26T23:22:14Z
dc.identifierNASCIMENTO, Clarissa Rodrigues et al. Monocytes from HTLV-1–infected patients are unable to fully mature into dendritic cells. Immunobiology, v. 117, n. 2, p. 489-499, Jan. 2011.
dc.identifier0171-2985
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36902
dc.identifier10.1182/blood-2010-03-272690
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889836
dc.descriptionHuman T-cell lymphotropic virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia and HTLV-1–associated myelopathy/tropical spastic paraparesis. HTLV-1–associated myelopathy/tropical spastic paraparesis is a chronic inflammatory disease characterized by loss of motor movement in response to spinal marrow cell destruction by T lymphocytes. To perform their cellular function, T cells need to be activated by antigenpresenting cells, such as dendritic cells (DCs). The aim of this work was to analyze DC differentiation and activation from monocytes of HTLV-1–infected individuals. We demonstrated that monocytes from HTLV-1–infected patients who had been stimulated to differentiate had an impaired loss of CD14 expression, expressed low levels of CD1a, and maintained secretion of tumor necrosis factor- compared with monocytes from noninfected donors. We further evaluated DC activation by tumor necrosis factor- α. We observed that in response to activation, DCs that were derived from noninfected donors had an increase in the percentage of CD83, CD86, and human leukocyte antigen-DR cells, whereas in DCs derived from HTLV-1–infected patients, the percentage of CD83, CD86, and human leukocyte antigen-DR cells remained similar to that of nonactivated cells. Moreover, these cells had an impaired capacity to stimulate allogeneic T lymphocytes. We demonstrated that DC maturation was altered in HTLV-1– infected patients, which could contribute to the development of HTLV-1–associated diseases.
dc.description2020-11-06
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.titleMonocytes from HTLV-1 infected patients are unable to fully maturate into dendritic cells
dc.typeArticle


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