Seroprevalence of antibodies against the three serotypes of poliovirus and IPV vaccine response in adult solid organ transplant candidates

dc.creatorBrandão, Luciana Gomes Pedro
dc.creatorSantoro-Lopes, Guilherme
dc.creatorOliveira, Silas de Souza
dc.creatorSilva, Edson Elias da
dc.creatorBrasil, Pedro Emmanuel Alvarenga Americano do
dc.date2019-07-12T14:44:27Z
dc.date2019-07-12T14:44:27Z
dc.date2018
dc.date.accessioned2023-09-26T23:21:57Z
dc.date.available2023-09-26T23:21:57Z
dc.identifierBRANDÃO, Luciana Gomes Pedro et al. Seroprevalence of antibodies against the three serotypes of poliovirus and IPV vaccine response in adult solid organ transplant candidates. Vaccine, v. 36, p. 4681-4686, July 2018.
dc.identifier0264-410X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34026
dc.identifier10.1016/j.vaccine.2018.06.031
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889783
dc.descriptionObjectives: To assess the prevalence of protective antibody titers to polioviruses in adults candidates for solid organ transplant (SOT), and to assess the immunogenic response to inactivated polio vaccine in this population. Methods: The study included SOT candidates referred to Immunization Reference Centre of Evandro Chagas National Institute of Infectious Diseases from March 2013 to January 2016. It was conducted in 2 phases. The first one, a cross-sectional seroprevalence study, followed by an uncontrolled analysis of vaccine response among patients without protective antibody titers at baseline. Antibody titers to poliomyelitis were determined by microneutralization assay.Results:Among 206 SOT candidates included, 156 (76%) had protective antibody titers to all poliovirus serotypes (95% CI: 70–81%). Proven history of oral vaccination in childhood was not associated with higher seroprevalence of protective antibody. In 97% of individuals without protective antibody titers at baseline, there was adequate vaccine response with one dose of inactivated polio vaccine. Conclusions: A relevant proportion of adult candidates for SOT does not have protective titers of antibodies to one or more poliovirus serotype. One dose of inactivated vaccine elicited protective antibody titersin 97% of these subjects and should be routinely prescribed prior to SOT.
dc.description2020-07-12
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectPoliomyelitis
dc.subjectImmunity
dc.subjectSeroprevalence
dc.subjectIPV vaccine
dc.titleSeroprevalence of antibodies against the three serotypes of poliovirus and IPV vaccine response in adult solid organ transplant candidates
dc.typeArticle


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