Prevalence and Risk Factors Associated With Anal Intraepithelial Neoplasia Among HIV-Positive Men in Brazil

dc.creatorMelo, Victor Hugo
dc.creatorGuimarães, Mark Drew Crosland
dc.creatorRocha, Gustavo Machado
dc.creatorAraujo, Angela Cristina Labanca
dc.creatorCarmo, Ricardo Andrade
dc.creatorGrinsztein, Beatriz
dc.creatorPilotto, José Henrique
dc.creatorPalefsky, Joel Michael
dc.date2017-02-07T10:10:07Z
dc.date2017-02-07T10:10:07Z
dc.date2014
dc.date.accessioned2023-09-26T23:21:50Z
dc.date.available2023-09-26T23:21:50Z
dc.identifierMELO, Victor Hugo; et al. Prevalence and Risk Factors Associated With Anal Intraepithelial Neoplasia Among HIV-Positive Men in Brazil. Journal of Lower Genital Tract Disease, v.18, n.2, p.128-135, 2014.
dc.identifier1089-2591
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17685
dc.identifier1526-0976
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889759
dc.descriptionObjective. This study aimed to assess the prevalence of, and associated factors with, anal intraepithelial neoplasia (AIN) among HIV-positive men evaluated at public health services in Brazil. Materials and Methods. This is a multicenter crosssectional study of HIV-positive male patients attending 6 public AIDS referral clinics in urban Brazil. Participants were interviewed for sociodemographic and behavioral characteristics. Anal swab specimens were collected for anal cytology and HPV DNA testing using L1 polymerase chain reaction. Univariate and multivariate analyses were performed to evaluate risk factors associated with the presence of low-grade squamous intraepithelial lesion (LSIL) and/or high-grade squamous intraepithelial lesion (HSIL). Results. Anal swabs were collected from 343 participants. Prevalence of LSIL/HSIL was 24.8%. The majority (60.1%) reported sexual intercourse with both men and women in their lifetime. At least 36.7% had 1 or more oncogenic HPV types. Four variables were independently associated with the presence of LSIL/HSIL in multivariate analysis: history of sex with both men and women (odds ratio [OR] = 4.8) or men only (OR = 6.2) compared with those having sex with women only; current cigarette smoking (OR = 2.2); current CD4+ level between 200 and 500 cells/mm3 (OR = 2.9) or below 200 cells/mm3 (OR = 3.8) compared with CD4+ level above 500 cells/mm3; and presence of oncogenic anal HPV infection (OR = 9.6). Conclusions. We found a high prevalence of AIN among HIV-positive men in Brazil. This population may serve as an important bridge population to women with implications for anogenital HPV infection in both men and women. Our findings confirm the need to assess screening programs for AIN among high-risk groups, similar to those used to prevent cervical cancer.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsrestricted access
dc.subjectInfecções por HIV
dc.subjectComportamento sexual
dc.subjectNeoplasias do Ânus
dc.subjectNeoplasia Intraepitelial anal
dc.subjectHomens
dc.subjectanus neoplasms
dc.subjectanal intraepithelial neoplasia
dc.subjectsexual behavior
dc.subjectHIV infections
dc.subjectMen
dc.titlePrevalence and Risk Factors Associated With Anal Intraepithelial Neoplasia Among HIV-Positive Men in Brazil
dc.typeArticle


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