Brasil
| Article
Replication of dengue viruses in mosquito cell cultures: a model from ultrastructural observations
| dc.creator | Barth, Ortrud Monika | |
| dc.date | 2020-09-20T21:09:35Z | |
| dc.date | 2020-09-20T21:09:35Z | |
| dc.date | 1992 | |
| dc.date.accessioned | 2023-09-26T23:21:12Z | |
| dc.date.available | 2023-09-26T23:21:12Z | |
| dc.identifier | BARTH, Ortrud Monika. Replication of dengue viruses in mosquito cell cultures: a model from ultrastructural observations. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 4, p. 565-574, Oct./Dec. 1992. | |
| dc.identifier | 0074-0276 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/43492 | |
| dc.identifier | 10.1590/S0074-02761992000400017 | |
| dc.identifier | 1678-8060 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8889643 | |
| dc.description | Mosquito cell cultures infected with human sera from dengue-1 and dengue-2 outbreaks, started in Rio de Janeiro by 1986 and 1990 respectively, were examined by electron microscopy at different times post the infection of cell cultures. More information was obtained about cell penetration of virus particles in the presence or not of antibodies, their pathway inside the cells, replication mode and exit. Infectiveness of the virus at those different stages can only be attributed to the particles appearing inside the trans-Golgi vesicles; most of all newly formed virus particles remain inside the RER-derived cell vesicles or inside lysosomes, even during cell lysis. Groups of larges particles, 65-75 nm in diameter at dengue-2 infections, persist during cell passage. The large amounts of smooth membrane structures, as vesicles or tabules inside the RER are attributed to a cell response to viral infection. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | |
| dc.rights | open access | |
| dc.subject | Flaviviridae | |
| dc.subject | Dengue tipo 1 | |
| dc.subject | Dengue tipo 2 | |
| dc.subject | Replicação do vírus | |
| dc.subject | Ultraestrutura | |
| dc.subject | Flaviviridae | |
| dc.subject | Dengue 1 | |
| dc.subject | Dengue 2 | |
| dc.subject | Virus replication | |
| dc.subject | Ultrastructure | |
| dc.title | Replication of dengue viruses in mosquito cell cultures: a model from ultrastructural observations | |
| dc.type | Article |