New approaches in antimalarial drug discovery and development - A Review

dc.creatorAguiar, Anna Caroline Campos
dc.creatorRocha, Eliana Maria Mauricio da
dc.creatorSouza, Nicolli Bellotti de
dc.creatorFrança, Tanos Celmar Costa
dc.creatorKrettli, Antoniana Ursine
dc.date2014-02-18T17:12:27Z
dc.date2014-02-18T17:12:27Z
dc.date2012
dc.date.accessioned2023-09-26T23:21:00Z
dc.date.available2023-09-26T23:21:00Z
dc.identifierAGUIAR, AnnCaroline Campos et al. New approaches in antimalarial drug discovery and development - A Review. Memórias do Instituto Oswaldo Cruz. 2012, vol.107, pp. 831-845.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7322
dc.identifier10.1590/S0074-02762012000700001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889605
dc.descriptionCNPq (MCT/CNPq/CT-Saúde/MS/SCTIE/DECIT), FAPEMIG, FIOCRUZ (PDTIS, PAPES V) AUK, ACCA, NBS and WJC have fellowships from CNPq.
dc.descriptionMalaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem has since been aggravated by a decreased sensitivity of Plasmodium vivax to chloroquine. This review discusses strategies for evaluating the antimalarial activity of new compounds in vitro and in animal models ranging from conventional tests to the latest high-throughput screening technologies. Antimalarial discovery approaches include the following: the discovery of antimalarials from natural sources, chemical modifications of existing antimalarials, the development of hybrid compounds, test-ing of commercially available drugs that have been approved for human use for other diseases and molecular model-ling using virtual screening technology and docking. Using these approaches, thousands of new drugs with known molecular specificity and active against P. falciparum have been selected. The inhibition of haemozoin formation in vitro, an indirect test that does not require P. falciparum cultures, has been described and this test is believed to improve antimalarial drug discovery. Clinical trials conducted with new funds from international agencies and the participation of several industries committed to the eradication of malaria should accelerate the discovery of drugs that are as effective as artemisinin derivatives, thus providing new hope for the control of malaria.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjecthuman malaria
dc.subjectPlasmodium falciparum
dc.subjectantimalarials
dc.subjectdrug screening
dc.subjectchloroquine
dc.subjectartemisinin
dc.subjectdrug resistance
dc.titleNew approaches in antimalarial drug discovery and development - A Review
dc.typeArticle


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