Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.

dc.creatorFigueiredo, Camila Alexandrina Viana
dc.creatorBarreto, Maurício Lima
dc.creatorNeves, Neuza Maria Alcântara
dc.creatorRodrigues, Laura Cunha
dc.creatorCooper, Philip John
dc.creatorCruz Filho, Alvaro Augusto Souza da
dc.creatorPontes-de-Carvalho, Lain Carlos
dc.creatorLemaire, Denise Carneiro
dc.creatorCosta, Ryan dos Santos
dc.creatorAmorim, Leila D
dc.creatorVergara, Candelaria
dc.creatorRafaels, Nicholas
dc.creatorGao, Li
dc.creatorFoster, Cassandra
dc.creatorCampbell, Monica
dc.creatorMathias, Rasika A
dc.creatorBarnes, Kathleen C
dc.date2014-08-22T19:26:05Z
dc.date2014-08-22T19:26:05Z
dc.date2013
dc.date.accessioned2023-09-26T23:20:48Z
dc.date.available2023-09-26T23:20:48Z
dc.identifierFIFUEIREDO, C. A. et al. Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Journal of Allergy Clinical Immunology, v. 131, n. 6, p. 1683-1690, 2013.
dc.identifier1097-6825
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8222
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889565
dc.descriptionBACKGROUND: Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. OBJECTIVE: We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. METHODS: Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti-A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. RESULTS: Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. CONCLUSIONS: Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Academy of Allergy, Asthma & Immunology
dc.rightsopen access
dc.subjectIL10
dc.subjectPolymorphisms
dc.subjectHelminth infection
dc.subjectImmune modulation
dc.subjectAllergy
dc.subjectAsthma
dc.subjectSocial changes asthma and allergy in Latin America
dc.subjectAsma/epidemiologia
dc.subjectAsma/etiologia
dc.subjectHelmintíase/complicações
dc.subjectInterleucina-10/biossíntese
dc.subjectPolimorfismo Genético
dc.subjectSons Respiratórios/etiologia
dc.subjectAdolescente
dc.subjectAlelos
dc.subjectBrasil/epidemiologia
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectFeminino
dc.subjectLigação Genética
dc.subjectGenótipo
dc.subjectHumanos
dc.subjectLactente
dc.subjectDesequilíbrio de Ligação
dc.subjectMasculino
dc.subjectPolimorfismo de Nucleotídeo Único
dc.subjectPopulação Urbana
dc.titleCoassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.
dc.typeArticle


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