Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model

dc.creatorBarros, Ana Paula D. N. de
dc.creatorTakiya, Christina M.
dc.creatorGarzoni, Luciana R.
dc.creatorFerreira, Mona Lisa Leal
dc.creatorDutra, Hélio S.
dc.creatorChiarini, Luciana B.
dc.creatorMeirelles, Maria Nazareth
dc.creatorBorojevic, Radovan
dc.creatorRossi, Maria Isabel D.
dc.date2018-08-08T12:20:32Z
dc.date2018-08-08T12:20:32Z
dc.date2010
dc.date.accessioned2023-09-26T23:19:49Z
dc.date.available2023-09-26T23:19:49Z
dc.identifierBARROS, Ana Paula D. N. de; et al. Osteoblasts and Bone Marrow Mesenchymal Stromal Cells Control Hematopoietic Stem Cell Migration and Proliferation in 3D In Vitro Model. PLoS ONE, v. 5, n.2, e9093, 13p, Feb. 2010.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27998
dc.identifier10.1371/journal.pone.0009093
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889380
dc.descriptionMigration, proliferation, and differentiation of hematopoietic stem cells (HSCs) are dependent upon a complex three-dimensional (3D) bone marrow microenvironment. Although osteoblasts control the HSC pool, the subendosteal niche is complex and its cellular composition and the role of each cell population in HSC fate have not been established. In vivo models are complex and involve subtle species-specific differences, while bidimensional cultures do not reflect the 3D tissue organization. The aim of this study was to investigate in vitro the role of human bone marrow-derived mesenchymal stromal cells (BMSC) and active osteoblasts in control of migration, lodgment, and proliferation of HSCs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectOsteoblastos
dc.subjectMedula óssea
dc.subjectMigração e proliferação
dc.subject3 D
dc.subjectCélulas Estromais Mesenquimais
dc.subjectcélulas-tronco hematopoiéticas
dc.subjectOsteoblasts
dc.subjectBone Marrow
dc.subjecthematopoietic stem cells
dc.subjectMesenchymal Stromal Cells
dc.subjectMigration and Proliferation
dc.subject3 D
dc.titleOsteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model
dc.typeArticle


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