Placenta analysis of prenatally diagnosed patients reveals early GAG storage in mucopolysaccharidoses II and VI

dc.creatorBaldo, Guilherme
dc.creatorMatte, Ursula
dc.creatorArtigalas, Osvaldo
dc.creatorSchwartz, Ida Vanessa
dc.creatorBurin, Maira Graeff
dc.creatorRibeiro, Erlane
dc.creatorHorovitz, Dafne Dain Gandelman
dc.creatorMagalhaes, Tatiana Pacheco
dc.creatorElleder, Milan
dc.creatorGiugliani, Roberto
dc.date2014-12-17T13:20:39Z
dc.date2014-12-17T13:20:39Z
dc.date2011
dc.date.accessioned2023-09-26T23:19:03Z
dc.date.available2023-09-26T23:19:03Z
dc.identifierBALDO, Guilherme. et al. Placenta analysis of prenatally diagnosed patients reveals early GAG storage in mucopolysaccharidoses II and VI. Molecular Genetics and Metabolism, Orlando, v. 103, p. 197-198, 2011.
dc.identifier1096-7192
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9195
dc.identifier10.1016/j.ymgme.2011.03.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8889237
dc.descriptionWe analyzed placental tissue in one fetus with MPS II (iduronate sulphatase deficiency) and another with MPS VI (arylsulfatase B deficiency). Both were diagnosed prenatally, but families decided to continue pregnancies and placentas were collected at birth. We were able to demonstrate early storage of GAGs in both diseases by GAG measurement and microscopy analysis. Our results suggest that some alterations related to MPS storage, although not pronounced, may be observed in placental tissue of patients affected by MPS II and MPS VI.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademic Press
dc.rightsrestricted access
dc.subjectMucopolysaccharidoses
dc.subjectHunter Syndrome
dc.subjectMaroteaux–Lamy Syndrome
dc.subjectPrenatal Diagnosis
dc.subjectGlycosaminoglycans
dc.subjectLysosomal Storage Diseases
dc.subjectMucopolissacaridoses
dc.subjectMucopolissacaridose II
dc.subjectMucopolissacaridose VI
dc.subjectDiagnóstico Pré-Natal
dc.subjectGlicosaminoglicanas
dc.subjectDoenças por Armazenamento dos Lisossomos
dc.titlePlacenta analysis of prenatally diagnosed patients reveals early GAG storage in mucopolysaccharidoses II and VI
dc.typeArticle


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