Evaluation of cardiac rhythm in dogs treated with levamisole hydrochloride using 24-hour ambulatory electrocardiography

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNogueira, Rodrigo B
dc.creatorSakate, Michiko
dc.creatorMatsubara, Beatriz B
dc.creatorde Souza Gonçalves, Renato
dc.creatorMagalhães Rosa, Guilherme J
dc.date2014-05-27T11:20:55Z
dc.date2016-10-25T18:18:58Z
dc.date2014-05-27T11:20:55Z
dc.date2016-10-25T18:18:58Z
dc.date2003-11-01
dc.date.accessioned2017-04-06T01:06:55Z
dc.date.available2017-04-06T01:06:55Z
dc.identifierJournal of Veterinary Cardiology, v. 5, n. 2, p. 29-32, 2003.
dc.identifier1760-2734
dc.identifierhttp://hdl.handle.net/11449/67450
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67450
dc.identifier10.1016/S1760-2734(06)70049-2
dc.identifier2-s2.0-34247367650
dc.identifierhttp://dx.doi.org/10.1016/S1760-2734(06)70049-2
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888894
dc.descriptionThe objective of this study was to evaluate the electrocardiographic alterations in the cardiac rhythm in dogs treated with levamisole hydrochloride over a period of 24 hours. Thirty-six mixed-breed dogs, both male and female, all clinically healthy, were used in the experiment. The dogs were divided into 6 groups with 6 dogs in each group, according to dosage and route of administration. The Holter test was initiated immediately after the treatment, and was maintained for 24 hours. In the group treated with 10 mg/kg by way of subcutaneous injection, one of them showed ventricular premature complexes, sometimes isolated and other times in pairs, and ventricular tachycardia, concentrated mainly in the first hour after administration of the drug. In the group of 6 animals treated subcutaneously with 25mg/kg, four showed isolated ventricular premature complexes, ventricular bigeminy and trigeminy, mainly during the first 2 hours after administration of the drug. All the animals in the other groups showed sinus arrhythmia followed by sinus arrest. The disturbances in the cardiac rhythm observed in clinically healthy animals treated with levamisole hydrochloride, indicate that it is preferable to avoid subcutaneous administration of levamisole hydrochloride and that the oral administration of the drug should be done with caution. © 2003 Elsevier B.V. All rights reserved.
dc.languageeng
dc.relationJournal of Veterinary Cardiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectexcipient
dc.subjectlevamisole
dc.subjectbreed
dc.subjectcontrolled study
dc.subjectdog disease
dc.subjectECG abnormality
dc.subjectelectrocardiography
dc.subjectfemale
dc.subjectheart arrhythmia
dc.subjectheart ventricle bigeminy
dc.subjectheart ventricle extrasystole
dc.subjectheart ventricle tachycardia
dc.subjectHolter monitoring
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsingle drug dose
dc.subjectsinus arrest
dc.subjectsinus arrhythmia
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleEvaluation of cardiac rhythm in dogs treated with levamisole hydrochloride using 24-hour ambulatory electrocardiography
dc.typeOtro


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