Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi

dc.creatorSilva, M. R. Simões
dc.creatorAraújo, J. S. de
dc.creatorPeres, R. B.
dc.creatorSilva, P. B. da
dc.creatorBatista, M. M.
dc.creatorAzevedo, L. D. de
dc.creatorBastos, M. M.
dc.creatorBahia, M. T.
dc.creatorBoechat, N.
dc.creatorSoeiro, Maria Nazaré C.
dc.date2019-09-17T12:50:22Z
dc.date2019-09-17T12:50:22Z
dc.date2019
dc.date.accessioned2023-09-26T23:17:26Z
dc.date.available2023-09-26T23:17:26Z
dc.identifierSILVA, M. R. Simões et al. Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi. Parasitology, v. 146, p. 1006-1012, Mar. 2019.
dc.identifier0031-1820
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/35627
dc.identifier10.1017/S0031182019000234
dc.identifier1469-8161
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888936
dc.descriptionChagas disease (CD) is a neglected parasitic condition endemic in the Americas caused by Trypanosoma cruzi. Patients present an acute phase that may or not be symptomatic, followed by lifelong chronic stage, mostly indeterminate, or with cardiac and/or digestive progressive lesions. Benznidazole (BZ) and nifurtimox are the only drugs approved for treatment but not effective in the late chronic phase and many strains of the parasite are naturally resistant. New alternative therapy is required to address this serious public health issue. Repositioning and combination represent faster, and cheaper trial strategies encouraged for neglected diseases. The effect of imatinib (IMB), a tyrosine kinase inhibitor designed for use in neoplasias, was assessed in vitro on T. cruzi and mammalian host cells. In comparison with BZ, IMB was moderately active against different strains and forms of the parasite. The combination IMB + BZ in fixed-ratio proportions was additive. Novel 14 derivatives of IMB were screened and a 3,2-difluoro-2-phenylacetamide (3e) was as potent as BZ on T. cruzi but had low selectivity index. The results demonstrate the importance of phenotypic assays, encourage the improvement of IMB derivatives to reach selectivity and testify to the use of repurposing and combination in drug screening for CD.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherCambridge University Press
dc.rightsrestricted access
dc.subjectDoença de Chagas
dc.subjectReaproveitamento de medicamentos
dc.subjectDerivados de imatinibe
dc.subjectIn vitro
dc.subjectChagas disease
dc.subjectDrug repurposing
dc.subjectImatinib
dc.subjectImatinib derivatives
dc.subjectin vitro
dc.subjectMesilato de Imatinib
dc.titleRepurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi
dc.typeArticle


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