What pre-Columbian mummies could teach us about South American leishmaniases?

dc.creatorSereno, Denis
dc.creatorAkhoundi, Mohammad
dc.creatorDorkeld, Franck
dc.creatorOury, Bruno
dc.creatorMoomen, Hooman
dc.creatorPerrin, Pascale
dc.date2020-11-27T18:47:16Z
dc.date2020-11-27T18:47:16Z
dc.date2017
dc.date.accessioned2023-09-26T23:15:54Z
dc.date.available2023-09-26T23:15:54Z
dc.identifierSERENO, Denis et al. What pre-Columbian mummies could teach us about South American leishmaniases?. Pathogens and Disease, v. 75, n. 3, 6p, ftx019, 2017.
dc.identifier2049-632X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44662
dc.identifier10.1093/femspd/ftx019
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888653
dc.descriptionA recent report on the taxonomic profile of the human gut microbiome in pre-Columbian mummies (Santiago-Rodriguez et al. 2016) gives for the first time evidence of the presence of Leishmania DNA (sequences similar to Leishmania donovani according to the authors) that can be reminiscent of visceral leishmaniasis during the pre-Columbian era. It is commonly assumed that Leishmania infantum, the etiological agent of American visceral leishmaniasis (AVL) was introduced into the New World by the Iberian conquest. This finding is really surprising and must be put into perspective with what is known from an AVL epidemiological and historical point of view. Beside L. infantum, there are other species that are occasionally reported to cause AVL in the New World. Among these, L. colombiensis is present in the region of pre-Columbian mummies studied. Other explanations for these findings include a more ancient introduction of a visceral species of Leishmania from the Old World or the existence of a yet unidentified endemic species causing visceral leishmaniasis in South America. Unfortunately, very few molecular data are known about this very long pre-Columbian period concerning the circulating species of Leishmania and their diversity in America.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectLeishmaniose visceral americana
dc.subjectEspécie leishmania patogênica
dc.subjectMúmias pré-colombianas
dc.subjectpre-Columbian mummies
dc.subjectPathogenic Leishmania species;
dc.subjectAmerican visceral leishmaniasis
dc.titleWhat pre-Columbian mummies could teach us about South American leishmaniases?
dc.typeArticle


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