The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching

dc.creatorMourier, Tobias
dc.creatorAlvarenga, Denise Anete Madureira de
dc.creatorKaushik, Abhinav
dc.creatorCosta, Anielle de Pina
dc.creatorDouvropoulou, Olga
dc.creatorGuan, Qingtian
dc.creatorGuzmán-Vega, Francisco J.
dc.creatorForrester, Sarah
dc.creatorAbreu, Filipe Vieira Santos de
dc.creatorBianco Júnior, Cesare
dc.creatorSouza Junior, Julio Cesar de
dc.creatorMoreira, Silvia Bahadian
dc.creatorHirano, Zelinda Maria Braga
dc.creatorPissinatti, Alcides
dc.creatorCruz, Maria de Fátima Ferreira da
dc.creatorOliveira, Ricardo Lourenço de
dc.creatorArold, Stefan T.
dc.creatorJeffares, Daniel C.
dc.creatorBrasil, Patrícia
dc.creatorBrito, Cristiana Ferreira Alves de
dc.creatorCulleton, Richard
dc.creatorRibeiro, Cláudio Tadeu Daniel
dc.creatorPain, Arnab
dc.date2021-11-05T14:32:43Z
dc.date2021-11-05T14:32:43Z
dc.date2021
dc.date.accessioned2023-09-26T23:15:41Z
dc.date.available2023-09-26T23:15:41Z
dc.identifierMOURIER, Tobias et al. The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching. BMC Biology, v. 19, n. 219, p. 1-17, 1 Oct. 2021.
dc.identifier1741-7007
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49709
dc.identifier10.1186/s12915-021-01139-5
dc.identifier1741-7007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888612
dc.descriptionBackground: Plasmodium simium, a malaria parasite of non-human primates (NHP), was recently shown to cause zoonotic infections in humans in Brazil. We sequenced the P. simium genome to investigate its evolutionary history and to identify any genetic adaptions that may underlie the ability of this parasite to switch between host species. Results: Phylogenetic analyses based on whole genome sequences of P. simium from humans and NHPs reveals that P. simium is monophyletic within the broader diversity of South American Plasmodium vivax, suggesting P. simium first infected NHPs as a result of a host switch of P. vivax from humans. The P. simium isolates show the closest relationship to Mexican P. vivax isolates. Analysis of erythrocyte invasion genes reveals differences between P. vivax and P. simium, including large deletions in the Duffy-binding protein 1 (DBP1) and reticulocyte-binding protein 2a genes of P. simium. Analysis of P. simium isolated from NHPs and humans revealed a deletion of 38 amino acids in DBP1 present in all human-derived isolates, whereas NHP isolates were multi-allelic. Conclusions: Analysis of the P. simium genome confirmed a close phylogenetic relationship between P. simium and P. vivax, and suggests a very recent American origin for P. simium. The presence of the DBP1 deletion in all human-derived isolates tested suggests that this deletion, in combination with other genetic changes in P. simium, may facilitate the invasion of human red blood cells and may explain, at least in part, the basis of the recent zoonotic infections.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectPlasmodium simium
dc.subjectPlasmodium vivax
dc.subjectMalária
dc.subjectZoonose
dc.subjectGenômica comparativa
dc.subjectPlasmodium simium
dc.subjectPlasmodium vivax
dc.subjectMalaria
dc.subjectZoonosis
dc.subjectComparative genomics
dc.titleThe genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching
dc.typeArticle


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