Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection

dc.creatorSouza, Robson da Paixão de
dc.creatorCardoso, Luciana Santos
dc.creatorLopes, Giuseppe Tittoni Varela
dc.creatorAlmeida, Maria Cecília F
dc.creatorOliveira, Ricardo Riccio
dc.creatorAlcântara, Leda Maria
dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorAraujo, Maria Ilma Andrade Santos
dc.date2018-07-03T19:19:41Z
dc.date2018-07-03T19:19:41Z
dc.date2012
dc.date.accessioned2023-09-26T23:15:23Z
dc.date.available2023-09-26T23:15:23Z
dc.identifierSOUZA, R. P. et al. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research, Article ID 394981, 2012.
dc.identifier2090-0023
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27258
dc.identifier10.1155/2012/394981
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888554
dc.descriptionOliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionFundação de Amparo à Pesquisa do Estado da (Bahia FAPESB) for the financial support. E. Carvalho and M. I. Araujo are investigators supported by The Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was supported by the Brazilian National Research Council (CNPq) Universal (482113/2010-3).
dc.descriptionPeriportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens. We evaluated the immune response in S. mansoni infected individuals with different degrees of periportal fibrosis. Cytokine and chemokines were measured in serum and in supernatants of PBMC cultures stimulated with the soluble adult worm (SWAP) or egg (SEA) antigens, using a sandwich ELISA. The levels of IL-5 in response to SEA were higher in individuals with moderate to severe fibrosis (310.9 pg/mL) compared to individuals without fibrosis (36.8 pg/mL; P = 0.0418). There was also a higher production of TNF-α in cultures stimulated with SWAP in patients with insipient fibrosis (1446 pg/mL) compared to those without fibrosis (756.1 pg/mL; P = 0.0319). The serum levels of IL-13 and MIP-1α were higher in subjects without fibrosis than in those with moderate to severe fibrosis. However a positive association between serum levels of IL-13, TNF-α, MIP-1α, and RANTES and S. mansoni parasite burden was found. From these data we conclude that IL-5 and TNF-α may participate in liver pathology in schistosomiasis. The positive association between IL-13, TNF-α, MIP-1α, and RANTES with parasite burden, however, might predict the development of liver pathology.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectSchistosoma mansoni
dc.subjectFibrose
dc.subjectInfecção
dc.subjectHumanos
dc.subjectCitocinas
dc.subjectSchistosoma mansoni
dc.subjectFibrosis
dc.subjectInfection
dc.subjectHumans
dc.subjectCytokine
dc.titleCytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection
dc.typeArticle


Este ítem pertenece a la siguiente institución