dc.creatorRodrigues, Ana Carolina Borges da Cruz
dc.creatorCosta, Rafaela G. A.
dc.creatorSilva, Suellen L. R.
dc.creatorDias, Ingrid R. S. B.
dc.creatorDias, Rosane Borges
dc.creatorBezerra, Daniel Pereira
dc.date2021-06-30T14:04:11Z
dc.date2021-06-30T14:04:11Z
dc.date2021
dc.date.accessioned2023-09-26T23:15:11Z
dc.date.available2023-09-26T23:15:11Z
dc.identifierRODRIGUES, Ana Carolina Borges da Cruz et al. Cell signaling pathways as molecular targets to eliminate AML stem cells. Critical Reviews in Oncology/Hematology, v. 160, p. 1-22, Apr. 2021.
dc.identifier1040-8428
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/47928
dc.identifier10.1016/j.critrevonc.2021.103277
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888522
dc.descriptionFundação de Amparo à Pesquisa da Bahia (FAPESB, Brazil)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil)
dc.descriptionAcute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLeucemia mielóide aguda
dc.subjectTransdução de Sinais
dc.subjectCélulas-tronco
dc.subjectTerapêutica
dc.subjectAcute myeloid leukemia
dc.subjectCell signaling
dc.subjectLeukemic stem cells
dc.subjectTarget therapy
dc.titleCell signaling pathways as molecular targets to eliminate AML stem cells
dc.typeArticle


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