Cell signaling pathways as molecular targets to eliminate AML stem cells

dc.creatorRodrigues, Ana Carolina Borges da Cruz
dc.creatorCosta, Rafaela G. A.
dc.creatorSilva, Suellen L. R.
dc.creatorDias, Ingrid R. S. B.
dc.creatorDias, Rosane Borges
dc.creatorBezerra, Daniel Pereira
dc.date2021-06-30T14:04:11Z
dc.date2021-06-30T14:04:11Z
dc.date2021
dc.date.accessioned2023-09-26T23:15:11Z
dc.date.available2023-09-26T23:15:11Z
dc.identifierRODRIGUES, Ana Carolina Borges da Cruz et al. Cell signaling pathways as molecular targets to eliminate AML stem cells. Critical Reviews in Oncology/Hematology, v. 160, p. 1-22, Apr. 2021.
dc.identifier1040-8428
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/47928
dc.identifier10.1016/j.critrevonc.2021.103277
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888522
dc.descriptionFundação de Amparo à Pesquisa da Bahia (FAPESB, Brazil)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil)
dc.descriptionAcute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLeucemia mielóide aguda
dc.subjectTransdução de Sinais
dc.subjectCélulas-tronco
dc.subjectTerapêutica
dc.subjectAcute myeloid leukemia
dc.subjectCell signaling
dc.subjectLeukemic stem cells
dc.subjectTarget therapy
dc.titleCell signaling pathways as molecular targets to eliminate AML stem cells
dc.typeArticle


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