dc.creator | Rodrigues, Ana Carolina Borges da Cruz | |
dc.creator | Costa, Rafaela G. A. | |
dc.creator | Silva, Suellen L. R. | |
dc.creator | Dias, Ingrid R. S. B. | |
dc.creator | Dias, Rosane Borges | |
dc.creator | Bezerra, Daniel Pereira | |
dc.date | 2021-06-30T14:04:11Z | |
dc.date | 2021-06-30T14:04:11Z | |
dc.date | 2021 | |
dc.date.accessioned | 2023-09-26T23:15:11Z | |
dc.date.available | 2023-09-26T23:15:11Z | |
dc.identifier | RODRIGUES, Ana Carolina Borges da Cruz et al. Cell signaling pathways as molecular targets to eliminate AML stem cells. Critical Reviews in Oncology/Hematology, v. 160, p. 1-22, Apr. 2021. | |
dc.identifier | 1040-8428 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/47928 | |
dc.identifier | 10.1016/j.critrevonc.2021.103277 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8888522 | |
dc.description | Fundação de Amparo à Pesquisa da Bahia (FAPESB, Brazil) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) | |
dc.description | Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.rights | restricted access | |
dc.subject | Leucemia mielóide aguda | |
dc.subject | Transdução de Sinais | |
dc.subject | Células-tronco | |
dc.subject | Terapêutica | |
dc.subject | Acute myeloid leukemia | |
dc.subject | Cell signaling | |
dc.subject | Leukemic stem cells | |
dc.subject | Target therapy | |
dc.title | Cell signaling pathways as molecular targets to eliminate AML stem cells | |
dc.type | Article | |