Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction

dc.creatorSantos, Isis Fernandes Magalhães
dc.creatorSouza, Márcia Maria de
dc.creatorLima, Carolina Silva Costa
dc.creatorAndrade, Sonia Gumes
dc.date2011-10-20T19:57:53Z
dc.date2011-10-20T19:57:53Z
dc.date2004
dc.date.accessioned2023-09-26T23:15:06Z
dc.date.available2023-09-26T23:15:06Z
dc.identifierSANTOS, Isis Fernandes Magalhães et al. Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 407-413, jun. 2004.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3265
dc.identifier10.1590/S0074-02762004000400011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888507
dc.descriptionThe influence of different Trypanosoma cruzi biodemes on the evolution of the infection and on the histopathological lesions of the heart and skeletal muscles, during the experimental infection of Calomys callosus, was investigated. Three groups of C. callosus were infected, respectively, with parasite strains representative of three different Biodemes: Type I (Y strain), Type II (21 SF strain), and Type III (Colombian strain). For each group, normal C. callosus were also used as controls. Marked differences have been detected in the responses of C. callosus to the infection with the three strains in this model. The strains Types I and II (Y and 21 SF) determined moderate lesions, mostly in the myocardium, with low parasitism, a rapid course, and total regression of the lesions by the 60th day of infection. Differently, Type III strain (Colombian), was more pathogenic for C. callosus and induced necrotic-inflammatory lesions in skeletal muscles and myocardium, in correspondence to intracellular parasitism. Proliferation of fibroblasts and amorphous matrix deposits, followed by interstitial fibrosis were present. Progressive regression of the inflammatory changes and collagen deposits occurred spontaneously. The progression and regression of both inflammation and fibrosis induced by the Colombian strain were further submitted to quantitative evaluation by morphometry. Results of the morphometric studies presented good correlation with the histopathological findings. The results confirm the importance of the different biodemes in the determination of tissue lesions and the peculiarities of response of C. callosus to infection with T. cruzi.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCalomys callosus
dc.subjectTrypanosoma cruzi
dc.subjectBiodemes
dc.subjectHistopathology
dc.subjectMorphometry fibrosis
dc.subjectInflammation
dc.subjectFatores de Tempo
dc.subjectTrypanosoma Cruzi
dc.subjectAnimais
dc.subjectMasculino
dc.subjectDoença de Chagas
dc.subjectFibrose
dc.subjectMúsculo Esquelético
dc.subjectMiocárdio
dc.subjectParasitemia
dc.subjectRoedores
dc.titleInfection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
dc.typeArticle


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