Probable corticosteroid-induced reactivation of latent hepatitis B virus infection in an HIV-positive patient involving immune escape

dc.creatorMartel, Nora
dc.creatorCotte, Laurent
dc.creatorTrabaud, Mary-Anne
dc.creatorTrepo, Christian
dc.creatorZoulim, Fabien
dc.creatorGomes, Selma A.
dc.creatorKay, Alan
dc.date2017-05-11T13:17:40Z
dc.date2017-05-11T13:17:40Z
dc.date2012
dc.date.accessioned2023-09-26T23:14:49Z
dc.date.available2023-09-26T23:14:49Z
dc.identifierMARTEL, Nora; et al. Probable Corticosteroid-Induced Reactivation of Latent Hepatitis B Virus Infection in an HIV-Positive Patient Involving Immune Escape. The Journal of Infectious Diseases, v.205, p.1757–61, 2012.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18814
dc.identifier10.1093/infdis/jis268
dc.identifier1537-6613
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888466
dc.descriptionWe describe a patient infected with human immunodeficiency virus who possessed a serological profile suggesting a previous cleared acute hepatitis B virus (HBV) infection, including high levels of antibodies against HBV surface antigen (anti-HBs). Following the administration of inhaled glucocorticosteroids combined with protease inhibitor-based antiretroviral treatment, the patient developed an unexpected severe acute hepatitis despite persistence of anti-HBs. A genotype A2 strain emerged with 2 major mutations in the S gene, sK122R and sD144E. Molecular and biological analyses strongly suggested reactivation of a latent HBV infection. The importance and the molecular basis of these 2 epitopes in immune-escape mechanisms and host-virus interactions are discussed.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectVírus da Hepatite B
dc.subjectHIV
dc.subjectPacientes
dc.subjectCorticosteróide
dc.subjectHepatitis B Virus Infection
dc.subjectHIV-Positive Patient
dc.subjectCorticosteroid
dc.titleProbable corticosteroid-induced reactivation of latent hepatitis B virus infection in an HIV-positive patient involving immune escape
dc.typeArticle


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