The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers

dc.creatorAmorim, Camila Farias
dc.creatorCarvalho, Natália Barbosa
dc.creatorAbraão Neto, José
dc.creatorSantos, Silvane Maria Braga
dc.creatorGrassi, Maria Fernanda Rios
dc.creatorCarvalho, Lucas Pedreira de
dc.creatorCarvalho, Edgar Marcelino de
dc.date2019-04-15T18:37:09Z
dc.date2019-04-15T18:37:09Z
dc.date2019
dc.date.accessioned2023-09-26T23:14:34Z
dc.date.available2023-09-26T23:14:34Z
dc.identifierAMOARIM, Camila Farias et al. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research, p. 1-10, 2019.
dc.identifier2314-8861
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32501
dc.identifier10.1155/2019/6574828
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888420
dc.descriptionInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais, which is financed by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) from Ministério da Ciência, Tecnologia, Inovações e Comunicações (grant number 465229/2014-0).
dc.descriptionThe cytotoxic activities of CD8+ T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1). As with CD8+ T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes. NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection. The aim of this study was to characterize the subsets and measure the frequency of NK cells in HTLV-1 carriers (HC) and in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and correlate these findings with the proviral load and development of HAM/TSP. The diagnosis of HTLV-1 infection was performed with a detection antibody against viral antigens by ELISA and confirmed by Western blot. Phenotypic characterization of NK cells was performed by flow cytometry. The frequencies of CD56+, CD56+CD3-, CD56+CD16+, and CD56dim cells were decreased in HAM/TSP patients. The frequency of CD56+CD3- cells was inversely correlated with proviral load in HC but not in HAM/TSP patients. HAM/TSP patients showed decreased frequency of CD56+ and CD56dim cells expressing CD16, the main receptor for ADCC. These data indicate that NK cells may play a key role in the control of HTLV-1 infection by preventing the progression of HC to HAM/TSP.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindwai
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectVírus Linfotrópico T Humano 1
dc.subjectCélulas NK
dc.subjectInfecção
dc.subjectHumanos
dc.subjectHTLV-1
dc.subjectHuman T-lymphotropic virus 1
dc.subjectKiller Cells, Natural
dc.subjectInfection
dc.subjectHumans
dc.titleThe Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers
dc.typeArticle


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