High prevalence of hepatitis A in indigenous population on north Brazil

dc.creatorPaula, Vanessa Salete de
dc.creatorMilagres, Flavio Augusto Pádua
dc.creatorOliveira, Guilherme de Macêdo
dc.creatorMiguel, Juliana Custódio
dc.creatorCruz, Helena Medina
dc.creatorScaloni, Letícia de Paula
dc.creatorMaques, Vanessa Alves
dc.creatorMagalhães, Monica de Avelar Figueiredo Mafra
dc.creatorRomão, Anselmo Rocha
dc.creatorGracie, Renata
dc.creatorVillar, Livia Melo
dc.date2020-12-27T18:57:44Z
dc.date2020-12-27T18:57:44Z
dc.date2020
dc.date.accessioned2023-09-26T23:14:18Z
dc.date.available2023-09-26T23:14:18Z
dc.identifierPAULA, Vanessa Salete de et al. High prevalence of hepatitis A in indigenous population in north Brazil. BMC Research Notes, v. 13, n. 458, p. 1-7, 2020.
dc.identifier1756-0500
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45440
dc.identifier10.1186/s13104-020-05303-y
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888368
dc.descriptionObjectives: Little is known about hepatitis A virus (HAV) prevalence in indigenous communities. This study aims to evaluate the prevalence of HAV in indigenous community compared to urban population located at Western Amazon in Brazil. Results: A total of 872 serum samples were obtained from 491 indigenous and 381 non indigenous individuals aging 0 to 90 years. Samples were tested for total and IgM anti-HAV and positive IgM samples were tested for HAV RNA. The overall prevalence of total anti-HAV was 87%, increased according age showing 100% of prevalence in those aging more than 30 years (p<0.0001) and it was similar among indigenous and urban population. Total anti-HAV prevalence varied between tribes (p<0.0001) and urban sites (p=0.0014) and spatial distribution showed high prevalence in homes that received up to 100 dollars. IgM anti-HAV prevalence was 1.7% with predominance in males, those aging more than 41 years. No HAV RNA was detected. In conclusion, high overall anti-HAV prevalence was found in indigenous communities in North Brazil demonstrating the importance of universal vaccination in this group.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectAlta prevalência
dc.subjectHepatite A
dc.subjectPopulação indígena
dc.subjectNorte do Brasil
dc.subjectHigh prevalence
dc.subjectHepatitis A
dc.subjectIndigenous population
dc.subjectNorth Brazil
dc.titleHigh prevalence of hepatitis A in indigenous population on north Brazil
dc.typeArticle


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