Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC

dc.creatorSilva, Taís Gusmão da
dc.creatorSilva, Josefa Carolaine Pereira da
dc.creatorCarneiro, Joara Nályda Pereira
dc.creatorAmaral, Wanderlei do
dc.creatorDeschamps, Cícero
dc.creatorAraújo, Jenifer Priscila de
dc.creatorCosta, José Galberto Martins da
dc.creatorAlmeida, Waltécio de Oliveira
dc.creatorSilva, Luiz Everson da
dc.creatorCoutinho, Henrique Douglas Melo
dc.creatorRibeiro Filho, Jaime
dc.creatorBraga, Maria Flaviana Bezerra Morais
dc.date2021-07-28T13:42:07Z
dc.date2021-07-28T13:42:07Z
dc.date2021
dc.date.accessioned2023-09-26T23:14:05Z
dc.date.available2023-09-26T23:14:05Z
dc.identifierSILVA, Taís Gusmão da et al. Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC. Archives of Microbiology, v. 203, n. 6, p. 3077-3087, 31 Mar. 2021.
dc.identifier0302-8933
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48389
dc.identifier10.1007/s00203-021-02304-8
dc.identifier1432-072X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888328
dc.descriptionFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico, FUNCAP for financial support
dc.descriptionThis study aimed to investigate the chemical composition and antifungal potential of the essential oil of Baccharis trimera (Less.) DC. against Candida strains. The half maximal inhibitory concentration (IC50) was assessed by the microdilution method using the essential oil at a concentration range of 8192 to 8 μg/mL. The minimum fungicide concentration (MFC) was determined by subculture in solid medium. The ability of the essential oil to modulate the activity of antifungals was determined in wells treated simultaneously with the oil at a subinhibitory concentration (MFC/16) and fluconazole (FCZ). The fungal morphology was analyzed by microscopy. Gas chromatography coupled with mass spectrometry (GC/MS) was used to identify the chemical composition. The essential oil presented an CI50 of 11.24 and 1.45 μg/mL, which was found to potentiate the effect of FCZ against Candida albicans. On the other hand, this combined treatment resulted in antagonism against Candida tropicalis and no evident modulation against Candida krusei was observed. The essential oil significantly inhibited hyphae growth. However, with a MFC ≥ 16,384 μg/mL, it is assumed that it has a fungistatic action. The antifungal properties demonstrated in this study might be related to the presence of sesquiterpenes and monoterpenes, and the interaction between them. In conclusion, Baccharis trimera showed promising anti-Candida effects, in addition to potentiating the activity of FCZ against Candida albicans, affecting its morphological transition. Therefore, this species constitutes a source of chemical compounds with the potential to be used in the combat of fungal infections.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsrestricted access
dc.subjectBaccharis
dc.subjectMonoterpenos
dc.subjectÓleos essenciais
dc.subjectanti-Candida
dc.subjectBaccharis trimera
dc.subjectTerpenes
dc.subjectEssential oils
dc.subjectAnti-Candida effect
dc.titlePhytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
dc.typeArticle


Este ítem pertenece a la siguiente institución