Discriminating acute from chronic human schistosomiasis mansoni

dc.creatorBeck, Lílian
dc.creatorVan-Lüme, Danielle S. M.
dc.creatorSouza, Joelma R.
dc.creatorDomingues, Ana L. C.
dc.creatorFavre, Tereza
dc.creatorAbath, Frederico Guilherme Coutinho
dc.creatorMontenegro, Silvia L. M.
dc.date2019-04-16T15:34:19Z
dc.date2019-04-16T15:34:19Z
dc.date2008
dc.date.accessioned2023-09-26T23:14:04Z
dc.date.available2023-09-26T23:14:04Z
dc.identifierBECK, Lilian et al. Discriminating acute from chronic human schistosomiasis mansoni. Acta Tropica, v. 108, p. 229–233, 2008.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32521
dc.identifier10.1016/j.actatropica.2008.08.012
dc.identifier1873-6254
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8888323
dc.descriptionSpecific immunoglobulin (IgA, IgG and IgM) responses to different antigen targets (soluble eggs antigen – SEA, soluble worm adult protein – SWAP and keyhole limpet hole – KLH) were measured by enzyme linked immunosorbent assay (ELISA) in patients with acute and chronic schistosomiasis, aswell as patients without schistosomiasis. SEA IgA and KLH IgM presented high discriminatory powers to distinguish acute from chronic schistosomiasis, with calculated areas under the curve (AUCs) of 0.88 and 0.82, respectively, obtained from receiver operating characteristic (ROC) curve. On the other hand, these tests, particularly SEA IgA were not useful to distinguish schistosomiasis (including the acute and chronic forms) from individuals without this disease, but infected with other intestinal parasites (Ascaris lumbricoides, Trichuris trichiura and hookworm). By contrast, SWAP IgG and SEA IgG were able to discriminate schistosomiasis patients from healthy individuals and patients infected with other parasites (AUCs of 0.96 and 0.85, respectively). Thus, it is possible to use a combination of serological tests, such as SEA IgA and SWAP IgG, to simultaneously establish the diagnosis of schistosomiasis and discriminate the acute from the chronic forms of the disease.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectDiagnóstico Diferencial
dc.subjectSchistosoma mansoni
dc.subjectCaracterísticas operacionais do receptor
dc.subjectEsquistossomose aguda
dc.subjectEsquistossomose crônica
dc.subjectDifferential diagnosis
dc.subjectSchistosoma mansoni
dc.subjectReceiver operating characteristic
dc.subjectAcute schistosomiasis
dc.subjectChronic schistosomiasis
dc.titleDiscriminating acute from chronic human schistosomiasis mansoni
dc.typeArticle


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