Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSpolidório, Luis Carlos
dc.creatorSpolidorio, D. M.
dc.creatorBenatti, C.
dc.creatorSampaio, J. E.
dc.creatorAlmeida, O. P.
dc.date2014-05-27T11:20:52Z
dc.date2016-10-25T18:18:48Z
dc.date2014-05-27T11:20:52Z
dc.date2016-10-25T18:18:48Z
dc.date2003-08-01
dc.date.accessioned2017-04-06T01:06:18Z
dc.date.available2017-04-06T01:06:18Z
dc.identifierJournal of Periodontal Research, v. 38, n. 4, p. 375-379, 2003.
dc.identifier0022-3484
dc.identifierhttp://hdl.handle.net/11449/67367
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67367
dc.identifier10.1034/j.1600-0765.2003.00014.x
dc.identifier2-s2.0-0141783727
dc.identifierhttp://dx.doi.org/10.1034/j.1600-0765.2003.00014.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888826
dc.descriptionBackground: Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity. Objective: The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently. Materials and methods: Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow. Results: Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine. Conclusion: These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.
dc.languageeng
dc.relationJournal of Periodontal Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAge
dc.subjectCyclosporin A
dc.subjectGingival overgrowth
dc.subjectNifedipine
dc.subjectcyclosporin
dc.subjectnifedipine
dc.subjectcalcium channel blocking agent
dc.subjectimmunosuppressive agent
dc.subjectage
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectconnective tissue
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectgingiva hyperplasia
dc.subjectmale
dc.subjectmouth mucosa
dc.subjectnonhuman
dc.subjectrat
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectchemically induced disorder
dc.subjectcomparative study
dc.subjectdrug combination
dc.subjectdrug potentiation
dc.subjectepithelium
dc.subjectgingiva overgrowth
dc.subjectWistar rat
dc.subjectAge Factors
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectCalcium Channel Blockers
dc.subjectConnective Tissue
dc.subjectCyclosporine
dc.subjectDrug Combinations
dc.subjectDrug Synergism
dc.subjectEpithelium
dc.subjectGingival Overgrowth
dc.subjectImmunosuppressive Agents
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.titleCombined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent
dc.typeOtro


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