Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection

dc.creatorCunha Jr, Luiz G.
dc.creatorAssis, Maria Cristina
dc.creatorMachado, Gloria Beatriz
dc.creatorAssef, Ana Paula
dc.creatorMarques, Elizabeth A.
dc.creatorLeão, Robson S.
dc.creatorSaliba, Alessandra M.
dc.creatorPlotkowski, Maria Cristina
dc.date2018-12-11T10:34:43Z
dc.date2018-12-11T10:34:43Z
dc.date2010
dc.date.accessioned2023-09-26T23:12:08Z
dc.date.available2023-09-26T23:12:08Z
dc.identifierCUNHA JR., Luiz G. et al. Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection. Respiratory Research, v.11, n.4, 9p, 2010.
dc.identifier1465-9921
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30499
dc.identifier1465-993X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887962
dc.descriptionBackground: Burkholderia cenocepacia, an opportunistic pathogen that causes lung infections in cystic fibrosis (CF) patients, is associated with rapid and usually fatal lung deterioration due to necrotizing pneumonia and sepsis, a condition known as cepacia syndrome. The key bacterial determinants associated with this poor clinical outcome in CF patients are not clear. In this study, the cytotoxicity and procoagulant activity of B. cenocepacia from the ET- 12 lineage, that has been linked to the cepacia syndrome, and four clinical isolates recovered from CF patients with mild clinical courses were analysed in both in vitro and in vivo assays.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectBurkholderia cenocepacia
dc.subjectinfecção respiratória
dc.subjectdisfunção aguda pulmonar
dc.subjectdisseminação extrapulmonar bacteriana
dc.subjectBurkholderia cenocepacia
dc.subjectacute lung dysfunction
dc.subjectbacterial extrapulmonary dissemination
dc.subjectrespiratory infection
dc.titlePotential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
dc.typeArticle


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