An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences

dc.creatorCarels, Nicolas
dc.creatorLeon, Miguel Ponce de
dc.date2017-09-12T18:07:06Z
dc.date2017-09-12T18:07:06Z
dc.date2015
dc.date.accessioned2023-09-26T23:12:01Z
dc.date.available2023-09-26T23:12:01Z
dc.identifierCARELS, N. et al. An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences. Bioinformatics and Biology Insights, v. 9, p. 37-47, 2015.
dc.identifier1177-9322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20983
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887942
dc.descriptionPurine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RW Y is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the product of a network of nucleotide compensations induced by functional constraints on the physicochemical properties of proteins. Through deductions from universal correlation properties, we also demonstrate that amino acids from Miller’s spark discharge experiment are compatible with functional primeval proteins at the dawn of living cell radiation on earth. These amino acids match the hydropathy and secondary structures of modern proteins.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSAGE Publishing
dc.rightsopen access
dc.subjectgenômica
dc.subjectcaracterísticas proteicas
dc.subjectcodon ancestral
dc.subjectgenomics
dc.subjectprotein features
dc.subjectancestral codon
dc.subjectpurine bias
dc.subjectshort-range correlations
dc.titleAn Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
dc.typeArticle


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