The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance

dc.creatorPassos, Geraldo Aleixo
dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorOliveira, Emma Hérida
dc.date2016-05-19T14:08:30Z
dc.date2016-05-19T14:08:30Z
dc.date2015
dc.date.accessioned2023-09-26T23:11:48Z
dc.date.available2023-09-26T23:11:48Z
dc.identifierPASSOS, Geraldo Aleixo; CRUZ, Daniella Arêas Mendes da; OLIVEIRA, Emma Hérida. The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance. Frontiers in Immunology, v.6, Article 352, 7p, July 2015.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/14392
dc.identifier10.3389/fimmu.2015.00352
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887900
dc.descriptionDeveloping thymocytes interact sequentially with two distinct structures within the thymus: the cortex and medulla. Surviving single-positive and double-positive thymocytes from the cortex migrate into the medulla, where they interact with medullary thymic epithelial cells (mTECs). These cells ectopically express a vast set of peripheral tissue antigens (PTAs), a property termed promiscuous gene expression that is associated with the presentation of PTAs by mTECs to thymocytes. Thymocyte clones that have a high affinity for PTAs are eliminated by apoptosis in a process termed negative selection, which is essential for tolerance induction. The Aire gene is an important factor that controls the expression of a large set of PTAs. In addition to PTAs, Aire also controls the expression of miRNAs in mTECs. These miRNAs are important in the organization of the thymic architecture and act as posttranscriptional controllers of PTAs. Herein, we discuss recent discoveries and highlight open questions regarding the migration and interaction of developing thymocytes with thymic stroma, the ectopic expression of PTAs by mTECs, the association between Aire and miRNAs and its effects on central tolerance.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectAIRE
dc.subjectmIRNA
dc.subjectMTEC
dc.subjectThymus gland
dc.subjectThymocites
dc.subjectCell adhesion
dc.subjectPromiscuous gene expression
dc.subjectCentral tolerance
dc.subjectMicroRNAs
dc.subjectTimo
dc.subjectAdesão Celular
dc.subjectTolerância Central
dc.titleThe thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
dc.typeArticle


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