Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance

dc.creatorBraga, Ana Lays
dc.creatorCruz, Rafael Pereira da
dc.creatorCarneiro, Joara Nalyda Pereira
dc.creatorSantos, Antonia Thassya Lucas dos
dc.creatorSales, Debora Lima
dc.creatorBezerra, Camila Fonseca
dc.creatorFonseca, Victor Juno Alencar
dc.creatorRocha, Janaina Esmeraldo
dc.creatorFreitas, Thiago Sampaio de
dc.creatorCampina, Fabia Ferreira
dc.creatorCosta, Maria do Socorro
dc.creatorAmaral, Wanderlei do
dc.creatorRebelo, Ricardo Andrade
dc.creatorSilva, Luiz Everson da
dc.creatorRibeiro Filho, Jaime
dc.creatorCoutinho, Henrique Douglas Melo
dc.creatorRodriguese, Fabíola Fernandes Galvão
dc.creatorBraga, Maria Flaviana Bezerra Morais
dc.date2021-08-26T18:58:04Z
dc.date2021-08-26T18:58:04Z
dc.date2021
dc.date.accessioned2023-09-26T23:10:27Z
dc.date.available2023-09-26T23:10:27Z
dc.identifierBRAGA, Ana Lays et al. Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance. South African Journal of Botany, 2021.
dc.identifier0254-6299
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48770
dc.identifier10.1016/j.sajb.2021.07.017
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887658
dc.descriptiona Universidade Regional do Cariri, URCA, Cel Ant^onio Luis, 1161, 63105-000, Pimenta, Crato, CE, Brazil b Universidade Federal do Paran a, UFPR, XV de Novembro, 1299, 80.060-000, Centro, Curitiba, PR, Brazil c Universidade Regional de Blumenau, FURB, Ant^onio da Veiga, 140, 89030-903, Itoupava Seca, Blumenau, SC, Brazil d Laborat orio de investiga¸c~ao em Gen etica e Hematologia Translacional, Instituto Gon¸calo Moniz (IGM), Funda¸c~ao Oswaldo Cruz (FIOCRUZ), Salvador, BA 40296- 710, Brazil e Centro Universit ario Doutor Le~ao Sampaio (Unile~ao), Av. Maria Letícia Leite Pereira s/n, Lagoa Seca, Juazeiro do Norte, Brazil
dc.descriptionPlant-derived essential oils are volatile hydrophobic compounds with significant antimicrobial activities. Considering the rise of antimicrobial resistance, these natural products have been highlighted as efficient weapons against multidrug-resistant microorganisms. This work aimed to investigate the phytochemical composition and antimicrobial activity of Piper regnellii essential oil against strains of Escherichia coli, Staphylococcus aureus, Candida albicans, and Candida tropicalis. Phytochemical analysis was performed through gas chromatography coupled with mass spectrometry (CG/MS). The intrinsic antimicrobial activity and the ability of the essential oil to modulate antimicrobial resistance were assessed using the broth microdilution method. Fungal virulence inhibition was analyzed by measuring the growth of hyphae in microculture chambers. Phytochemical characterization revealed a predominance of phenylpropanoids, including apiol (70.79%) and dilapiol (15.05%) as major constituents. While presenting clinically ineffective antibacterial effects (MIC 1.024 mg/mL for all strains), the essential oil potentiated the activity of gentamicin against E. coli at concentrations above 20 mg/mL. Piper regnellii essential oil showed clinically ineffective antifungal activity with IC50 values above 500 mg/mL. However, it was found to potentiate the activity of fluconazole against C. tropicalis at concentrations ranging from 32 mg/mL to 1024 mg/mL. Furthermore, the morphological transition was inhibited by culturing C. albicans and C. tropicalis with different concentrations of the essential oil. Together, our results indicate that P. regnellii essential oil presents promising antifungal effects. However, the mechanisms underlying its interference on Candida virulence remain to be further investigated.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectPiper regnellii
dc.subjectEscherichia coli
dc.subjectFluconazol
dc.subjectCandida tropicalis
dc.subjectResistência antimicrobiana
dc.subjectPiper regnellii
dc.subjectEssential oil
dc.subjectAntifungal
dc.subjectCandida virulence
dc.subjectAntimicrobial resistance
dc.titlePiper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance
dc.typeArticle


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