Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.

dc.creatorTitus, Richard G
dc.creatorDekrey, Gregory K
dc.creatorMorris, Robin V
dc.creatorSoares, Milena Botelho Pereira
dc.date2015-04-07T17:24:36Z
dc.date2015-04-07T17:24:36Z
dc.date2001
dc.date.accessioned2023-09-26T23:09:44Z
dc.date.available2023-09-26T23:09:44Z
dc.identifierTITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.
dc.identifier0104-5695
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9911
dc.identifier10.1128/IAI.69.8.5189–5192.2001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887534
dc.descriptionSince interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.rightsopen access
dc.subjectCitocinas/genética
dc.subjectRegulação da Expressão Gênica
dc.subjectInterleucina-6/imunologia
dc.subjectLeishmania major/imunologia
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectAnimais
dc.subjectSuscetibilidade a Doenças/imunologia
dc.subjectRegulação para Baixo
dc.subjectInterleucina-6/genética
dc.subjectLeishmaniose Cutânea/genética
dc.subjectLeishmaniose Cutânea/fisiopatologia
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectCamundongos Knockout
dc.subjectCélulas Th1/imunologia
dc.titleInterleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
dc.typeArticle


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