Sexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples

dc.creatorRodrigues, Luana L. S.
dc.creatorHardick, Justin
dc.creatorNicol, Alcina F.
dc.creatorMorgado, Mariza G.
dc.creatorMartinelli, Katrini G.
dc.creatorPaula, Vanessa S. de
dc.creatorPilotto, José H.
dc.creatorGaydos, Charlotte A.
dc.date2019-06-04T12:56:03Z
dc.date2019-06-04T12:56:03Z
dc.date2019
dc.date.accessioned2023-09-26T23:09:24Z
dc.date.available2023-09-26T23:09:24Z
dc.identifierRODRIGUES, Luana L. S. et al. Sexually transmitted infections among HIVinfected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: self-collected vs. clinician-collected samples. Plos One, v. 14, n. 4, p. 1-21, Apr. 23, 2019.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33354
dc.identifier10.1371/journal.pone.0215001
dc.identifier1932-6203
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887473
dc.descriptionThe anogenital prevalence of sexually transmitted infections (STIs) and the use of cervico-vaginal self-collected vs. clinician-collected samples were evaluated for the diagnosis of human immunodeficiency virus (HIV)-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil. We recruited 153 women for a cross-sectional study (112 HIV-uninfected and 41 HIV-infected) who sought health services. Anal and cervical scrapings and cervico-vaginal self-collection samples were collected. Real-time polymerase chain reaction methods were used for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Mycoplasma genitalium. A syphilis test was also performed. Risk factors for STIs were identified by multivariate analysis. The overall prevalence of STIs was 30.4% (34/112) in HIV-uninfected women and 24.4% (10/41) in HIV-infected women. Anogenital Chlamydia trachomatis infection was the most prevalent in both groups of women (20.5% vs 19.5%). There was significant agreement for each STI between self-collected and clinician-collected samples: 91.7%, kappa 0.67, 95% confidence interval (CI) 0.49-0.85 for Chlamydia trachomatis; 99.2%, kappa 0.85, 95% CI 0.57-1.00 for Neisseria gonorrhoeae; 97.7%, kappa 0.39, 95% CI -0.16-0.94 for Trichomonas vaginalis; and 94.7%, kappa 0.51, 95% CI 0.20-0.82 for Mycoplasma genitalium. Women with human papillomavirus had coinfection or multiple infections with other STIs. Risk factors for STIs were being ≤ 25 years old, being employed or a student, reporting a history of STI and having a positive HPV test. A high prevalence of STIs in women in the Tapajós region was found. Cervico-vaginal self-collection is a useful tool for STI screening and can be used in prevention control programs in low-resource settings, such as in northern Brazil.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectHIV
dc.subjectWomen
dc.subjectTapajós region
dc.subjectAmazon
dc.subjectBrazil
dc.titleSexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples
dc.typeArticle


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