Overview of the organization of protease genes in the genome of Leishmania spp

dc.creatorAlmeida, Mariana Silva
dc.creatorSilva, Franklin Souza
dc.creatorPereira, Bernardo Acácio Santini
dc.creatorGuimarães, Michelle Lopes Ribeiro
dc.creatorAlves, Carlos Roberto
dc.date2015-05-04T16:34:36Z
dc.date2015-05-04T16:34:36Z
dc.date2014
dc.date.accessioned2023-09-26T23:08:14Z
dc.date.available2023-09-26T23:08:14Z
dc.identifierALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014.
dc.identifier1756-3305
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10183
dc.identifier10.1186/1756-3305-7-387
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887250
dc.descriptionBackground: The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore classified as virulence factors. Findings: By analyzing protease genes annotated in the genomes of four Leishmania spp [Leishmania (Leishmania) infantum, L. (L.) major, L. (L.) mexicana and L. (Viannia) braziliensis], these genes were found on every chromosome of these protozoa. Four protease classes were studied: metallo-, serine, cysteine and aspartic proteases. Metalloprotease genes predominate in the L. (V.) braziliensis genome, while in the other three species studied, cysteine protease genes prevail. Notably, cysteine and serine protease genes were found to be very abundant, as they were found on all chromosomes of the four studied species. In contrast, only three aspartic protease genes could be detected in these four species. Regarding gene conservation, a higher number of conserved alleles was observed for cysteine proteases (42 alleles), followed by metalloproteases (35 alleles) and serine proteases (15 alleles). Conclusions: The present study highlights substantial differences in the organization of protease genes among L. (L.) infantum, L. (L.) major, L. (L.) mexicana and L. (V.) braziliensis. We observed significant distinctions in many protease features, such as occurrence, quantity and conservation. These data indicate a great diversity of protease genes among Leishmania species, an aspect that may be related to their adaptations to the peculiarities of each microenvironment they inhabit, such as the gut of phlebotomines and the immune cells of vertebrate hosts.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectLeishmania
dc.subjectLeishmania
dc.subjectLeishmania (Viannia) braziliensis
dc.subjectLeishmania (Leishmania) infantum
dc.subjectLeishmania (Leishmania) major
dc.subjectLeishmania (Leishmania) mexicana
dc.subjectProteases
dc.subjectLeishmania
dc.subjectPeptídeo Hidrolases
dc.titleOverview of the organization of protease genes in the genome of Leishmania spp
dc.typeArticle


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